Department of Radiology, Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Eur Radiol. 2012 Mar;22(3):682-7. doi: 10.1007/s00330-011-2295-z. Epub 2011 Oct 9.
To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation.
DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study (n = 34) and control groups' (n = 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores.
The mean ADC value of the liver was smaller in the study group compared with the control group (P < 0.001). Spearman rho correlation analyses showed lower ADC values were associated with higher fibrosis and HAI scores (P < 0.01). There were statistically significant differences in liver ADC values between each combination of fibrosis stages (e.g. stages 0 and 1, 0 and 2) except for stages 1 and 2.
ADC values prove to be a valuable technique for the diagnosis of liver fibrosis and inflammation. They can also be useful in fibrosis staging, particularly in distinguishing later stages of fibrosis from intermediate and early stages.
Diffusion Weighted MRI is a promising technique for diagnosis of liver fibrosis. Apparent Diffusion Coefficients provide valuable information for staging of liver fibrosis. DWI may offer alternative to biopsy for assessing liver fibrosis.
评估弥散加权磁共振成像（DWI）在检测和分期肝纤维化和炎症中的作用。
采用 b 值为 0、500 和 1000 s/mm² 的 DWI。通过在肝脏的四个节段放置圆形感兴趣区来获得 ADC 值。检查研究组（n=34）和对照组（n=25）的 ADC 值差异。此外，本研究还探讨了 ADC 值与纤维化分期和组织学活动指数（HAI）评分之间的关系。
研究组肝脏的平均 ADC 值明显低于对照组（P<0.001）。Spearman rho 相关分析表明，较低的 ADC 值与较高的纤维化和 HAI 评分相关（P<0.01）。在每个纤维化分期组合之间（例如，0 期和 1 期、0 期和 2 期），肝脏 ADC 值存在统计学显著差异，但 1 期和 2 期除外。
ADC 值证明是诊断肝纤维化和炎症的一种有价值的技术。它们在纤维化分期中也很有用，特别是在区分纤维化的晚期与中早期阶段。
弥散加权磁共振成像技术是肝纤维化诊断的有前途的方法。表观弥散系数为肝纤维化分期提供了有价值的信息。DWI 可能为评估肝纤维化提供替代活检的方法。
