Murayama Norihide, Murayama Kikuno
MURAYAMA Pediatrics, 3-2-33 Nagayoshi-Nagahara-Higashi, Hirano-ku, Osaka-shi, Osaka 547-0013, Japan.
Pulm Med. 2018 Mar 13;2018:1648652. doi: 10.1155/2018/1648652. eCollection 2018.
Ultrasonic, jet, and mesh nebulizers have all been used in the treatment for asthma. Mesh nebulizers reportedly offer the best inhalation efficiency.
This study aimed to clarify the utility of the mesh nebulizer, compared to jet nebulizers, in the treatment of pediatric asthma patients. Participants included 88 children <6 years old who were receiving treatment for asthma at Murayama Pediatric Clinic. Heart rate, peripheral oxygen saturation in arterial blood, and Mitsui symptom scores were compared before and after treatment with a mesh nebulizer ( = 43) or jet nebulizer ( = 45) using a salbutamol inhalation solution (0.2 ml for children ≧ 2 years old, = 51; 0.1 ml for children < 2 years old, = 37).
Other than required inhalation time, clinical findings did not differ between mesh and jet groups. In both groups, heart rate increased significantly in patients treated with 0.2 ml (1000 microg) of salbutamol.
The required inhalation time of the mesh nebulizer was superior to the jet nebulizer. Children ≧ 2 years with mild asthma attacks experienced a significantly increased heart rate in both groups. The dose of salbutamol (0.2 ml for ≧2 years) used for asthma attacks should be reconsidered in mild asthma.
超声雾化器、喷射雾化器和网式雾化器均已用于哮喘治疗。据报道，网式雾化器的吸入效率最佳。
本研究旨在阐明与喷射雾化器相比，网式雾化器在治疗小儿哮喘患者中的效用。研究对象包括在村山儿科诊所接受哮喘治疗的88名6岁以下儿童。使用沙丁胺醇吸入溶液（2岁及以上儿童0.2毫升，n = 51；2岁以下儿童0.1毫升，n = 37），对使用网式雾化器（n = 43）或喷射雾化器（n = 45）治疗前后的心率、动脉血氧饱和度和三井症状评分进行比较。
除所需吸入时间外，网式雾化器组和喷射雾化器组的临床结果无差异。在两组中，使用0.2毫升（1000微克）沙丁胺醇治疗的患者心率显著增加。
网式雾化器所需的吸入时间优于喷射雾化器。在两组中，2岁及以上轻度哮喘发作儿童的心率显著增加。对于轻度哮喘，应重新考虑用于哮喘发作的沙丁胺醇剂量（2岁及以上为0.2毫升）。
