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本文引用的文献

1
Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation.在机械通气过程中,雾化器类型、位置和偏流对模拟儿科和成人肺部模型中气溶胶药物输送的影响。
Respir Care. 2010 Jul;55(7):845-51.
2
Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures.使用空气喷射雾化器和具有大网孔的新型微泵装置递送的脂质体的物理稳定性和气溶胶特性。
Int J Pharm. 2007 Apr 4;334(1-2):62-70. doi: 10.1016/j.ijpharm.2006.10.022. Epub 2006 Oct 21.
3
Aerosol deposition in neonatal ventilation.新生儿通气中的气溶胶沉积。
Pediatr Res. 2005 Jul;58(1):10-4. doi: 10.1203/01.PDR.0000156244.84422.55. Epub 2005 Mar 17.
4
Nebulizers that use a vibrating mesh or plate with multiple apertures to generate aerosol.使用带有多个小孔的振动网或板来产生气雾剂的雾化器。
Respir Care. 2002 Dec;47(12):1406-16; discussion 1416-8.
5
Importance of drug delivery system in steroid aerosol therapy via nebulizer.药物递送系统在通过雾化器进行类固醇气雾剂治疗中的重要性。
Pulm Pharmacol Ther. 2002;15(5):449-54. doi: 10.1006/pupt.2002.0386.
6
Special problems in aerosol delivery: neonatal and pediatric considerations.气雾剂给药的特殊问题:新生儿和儿科方面的考虑因素
Respir Care. 2000 Jun;45(6):646-51.
7
The science of nebulised drug delivery.雾化药物递送科学。
Thorax. 1997 Apr;52 Suppl 2(Suppl 2):S31-44. doi: 10.1136/thx.52.2008.s31.
8
The delivery of therapeutic aerosols through endotracheal tubes.通过气管内导管输送治疗性气雾剂。
Pediatr Pulmonol. 1986 Jan-Feb;2(1):19-26. doi: 10.1002/ppul.1950020108.

使用振动筛孔雾化器治疗严重术中支气管痉挛。

Severe intraoperative bronchospasm treated with a vibrating-mesh nebulizer.

作者信息

Golden Leonard R, DeSimone Helen Ann, Yeroshalmi Farhad, Pranevicius Mindaugas, Saraghi Mana

机构信息

Chairman, Department of Anesthesiology, Jacobi Medical Center, Bronx, NY, USA.

出版信息

Anesth Prog. 2012 Fall;59(3):123-6. doi: 10.2344/12-00003.1.

DOI:10.2344/12-00003.1
PMID:23050752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3468290/
Abstract

Bronchospasm and status asthmaticus are two of the most dreaded complications that a pediatric anesthesiologist may face. With the occurrence of severe bronchospasm and the inability to ventilate, children are particularly vulnerable to apnea and ensuing hypoxia because of their smaller airway size, smaller lung functional residual capacity, and higher oxygen consumption rates than adults. Nebulized medication delivery in intubated children is also more difficult because of smaller endotracheal tube internal diameters. This case demonstrates the potentially lifesaving use of a vibrating-mesh membrane nebulizer connected to the anesthesia circuit for treating bronchospasm.

摘要

支气管痉挛和哮喘持续状态是儿科麻醉医生可能面临的两种最可怕的并发症。由于严重支气管痉挛的发生以及无法进行通气,儿童因其气道尺寸较小、肺功能残气量较小以及氧消耗率高于成人,特别容易发生呼吸暂停和随之而来的缺氧。由于气管内导管内径较小,给插管儿童雾化给药也更加困难。本病例展示了连接到麻醉回路的振动筛孔膜雾化器在治疗支气管痉挛方面可能挽救生命的应用。