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联合起来更强大：转移性癌症中的循环肿瘤细胞聚集。

Better together: circulating tumor cell clustering in metastatic cancer.

机构信息

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

出版信息

Trends Cancer. 2021 Nov;7(11):1020-1032. doi: 10.1016/j.trecan.2021.07.001. Epub 2021 Sep 1.

DOI:10.1016/j.trecan.2021.07.001
PMID:34481763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8541931/
Abstract

Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific dogma focuses on metastasis mediated by single CTCs, but advancement of CTC detection technologies has elucidated multicellular CTC clusters, which are associated with unfavorable clinical outcomes and a 20- to 100-fold greater metastatic potential than single CTCs. While the mechanistic understanding of CTC cluster formation is still in its infancy, multiple cell adhesion molecules and tight junction proteins have been identified that underlie the outperforming attributes of homotypic and heterotypic CTC clusters, such as cell survival, cancer stemness, and immune evasion. Future directions include high-resolution characterization of CTCs at multiomic levels for diagnostic/prognostic evaluations and targeted therapies.

摘要

循环肿瘤细胞 (CTCs) 是液体活检诊断残留癌症、监测治疗反应和预测复发的重要组成部分。科学理论主要关注单个 CTC 介导的转移，但 CTC 检测技术的进步已经阐明了多细胞 CTC 簇，这些簇与不良的临床结局以及比单个 CTC 高出 20 到 100 倍的转移潜力相关。虽然对 CTC 簇形成的机制理解仍处于起步阶段，但已经确定了多种细胞黏附分子和紧密连接蛋白，这些分子是同质和异质 CTC 簇表现出优异特性的基础，例如细胞存活、癌症干性和免疫逃逸。未来的方向包括在多组学水平上对 CTC 进行高分辨率的特征描述，以进行诊断/预后评估和靶向治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/d5a658703785/nihms-1738968-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/587ba4695f4f/nihms-1738968-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/2322ae0af220/nihms-1738968-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/d5a658703785/nihms-1738968-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/587ba4695f4f/nihms-1738968-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/2322ae0af220/nihms-1738968-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effc/8541931/d5a658703785/nihms-1738968-f0003.jpg

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