Rahgoshai S, Mohammadi M, Refahi S, Oladghaffari M, Aghamiri S M R
Department of Medical radiation Science, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Assistant Professor of Medical Physics, Department of Medical Physics, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
J Biomed Phys Eng. 2018 Mar 1;8(1):133-140. eCollection 2018 Mar.
Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells. Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells Cimetidine was found more effective when used in vivo; this effect might be due to the augmentation of the presence of Sulphur atom in the compound which is ýimportant for their scavenging activity. Recently, a new herbal-based medicine with immunomodulatory capacities, Setarud (IMOD), was introduced as an additional therapy in various inflammatory diseases and HIV infection. IMOD is a mixture of herbal extracts enriched with selenium. Selenium confers protection by inducing or activating cellular free-radical scavenging systems and by enhancing peroxide breakdown. This article suggests that nontoxic amount of IMOD and cimetidine have radioprotective properties and could reduce cytotoxic effects of radiation.
辐射损伤在很大程度上是由活性氧（ROS）的过度产生引起的。辐射防护剂是指在保持肿瘤细胞对辐射损伤敏感性的同时，能减轻辐射对健康正常组织影响的药物或物质。西咪替丁在体内使用时被发现更有效；这种效果可能是由于化合物中硫原子含量的增加，而硫原子对其清除活性很重要。最近，一种具有免疫调节能力的新型草药制剂Setarud（IMOD）被引入，作为各种炎症性疾病和HIV感染的辅助疗法。IMOD是富含硒的草药提取物的混合物。硒通过诱导或激活细胞自由基清除系统以及增强过氧化物分解来提供保护。本文表明，无毒剂量的IMOD和西咪替丁具有辐射防护特性，并且可以降低辐射的细胞毒性作用。
