Paydary Koosha, Emamzadeh-Fard Sahra, Khorram Khorshid Hamid Reza, Kamali Koorosh, SeyedAlinaghi SeyedAhmad, Mohraz Minoo
Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.
Recent Pat Antiinfect Drug Discov. 2012 Apr;7(1):66-72. doi: 10.2174/157489112799829756.
The broad use of highly active anti-retroviral therapy (HAART), especially in developing world, has been associated with several problems such as lactic acidosis, lipodistrophy, pancreatitis, hyperlipidemia, insulin resistance and hepatotoxicity. Extensive use of HAART has also resulted in emergence of resistant HIV variants. Thereby, a pressing need for development of novel and cost-effective agents arises from these limitations. Setarud (IMOD™) is a safe, naturally- derived immunomodulator that was introduced for treatment of HIV patients in Iran. It is prepared as a mixture of herbal extracts including Tanacetum vulgare (tansy), Rosa canina and Urtica dioica (nettle) in addition to selenium, flavonoids and carotenes. Tanacetum vulgare may relieve anti-inflammatory symptoms and Rosa canina defers blood glucose and cholesterol elevation. Extracts from Urtica dioica may prevent maturation of myeloid dendritic cells and reduce T cell responses. A significant rise of CD4 count was observed in HIV patients treated by IMOD™ in clinical trial phases, which could be explained by its immunomodulatory effects. Anti-oxidative activity of compounds in IMOD™ might play a role in the clinical outcomes of patients treated with this drug. Moreover, IMOD™ may show improving activity upon lipid profile and liver metabolism. According to studies on IMOD™, it seems that IMOD™ has minor side effects. IMOD™ with international publication number WO 2007/087825 A1 is an herbal extract which includes Rosa canina, Urtica dioica, Tanacetum vulgare, and selenium comprising a treatment by pulsed electromagnetic field of high frequency and is useful in treatment of HIV infection and AIDS.
高效抗逆转录病毒疗法（HAART）的广泛应用，尤其是在发展中世界，已引发了若干问题，如乳酸酸中毒、脂肪代谢障碍、胰腺炎、高脂血症、胰岛素抵抗和肝毒性。HAART的广泛使用还导致了耐药HIV变体的出现。因此，由于这些局限性，迫切需要开发新型且具有成本效益的药物。Setarud（IMOD™）是一种安全的天然免疫调节剂，已在伊朗用于治疗HIV患者。它是作为一种草药提取物的混合物制备而成，除了含有硒、类黄酮和胡萝卜素外，还包括艾菊、犬蔷薇和荨麻。艾菊可能缓解炎症症状，犬蔷薇可延缓血糖和胆固醇升高。荨麻提取物可能会阻止髓样树突状细胞成熟并降低T细胞反应。在临床试验阶段，接受IMOD™治疗的HIV患者的CD4细胞计数显著上升，这可以用其免疫调节作用来解释。IMOD™中化合物的抗氧化活性可能在接受该药物治疗的患者的临床结果中发挥作用。此外，IMOD™可能对脂质谱和肝脏代谢有改善作用。根据对IMOD™的研究，似乎IMOD™的副作用较小。国际公开号为WO 2007/087825 A1的IMOD™是一种草药提取物，包含犬蔷薇、荨麻、艾菊和硒，其采用高频脉冲电磁场进行处理，可用于治疗HIV感染和艾滋病。
