Okuyama Satoshi, Shinoka Wakana, Nakamura Kumi, Kotani Maho, Sawamoto Atsushi, Sugawara Kuniaki, Sudo Masahiko, Nakajima Mitsunari, Furukawa Yoshiko
a Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences , Matsuyama University , Matsuyama , Japan.
b Department of Planning and Development , Ehime Beverage Inc. , Matsuyama , Japan.
Biosci Biotechnol Biochem. 2018 Aug;82(8):1384-1395. doi: 10.1080/09168451.2018.1469396. Epub 2018 May 6.
We previously reported that the dried peel powder of Citrus kawachiensis exerted anti-inflammatory effects in the brain in several animal models. Hyperglycemia induces inflammation and oxidative stress and causes massive damage in the brain; therefore, we herein examined the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the streptozotocin-induced hyperglycemia mice model and in the type 2 diabetic db/db mice model. The C. kawachiensis administration inhibited microglial activation in the hippocampus in the streptozotocin-injected mice. Moreover, The C. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau at 231 of threonine and 396 of serine in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the db/db mice. It was suggested that the dried peel powder of C. kawachiensis exerts anti-inflammatory and neuroprotective effects in the brain.
我们之前报道过，川橘干燥果皮粉在多种动物模型中对大脑具有抗炎作用。高血糖会引发炎症和氧化应激，并对大脑造成严重损害；因此，我们在此研究了川橘干燥果皮粉对链脲佐菌素诱导的高血糖小鼠模型和2型糖尿病db/db小鼠模型的抗炎及其他作用。给予川橘可抑制链脲佐菌素注射小鼠海马中的小胶质细胞活化。此外，川橘处理可抑制db/db小鼠海马中的星形胶质细胞活化以及海马神经元中苏氨酸231和丝氨酸396处tau的过度磷酸化，还可缓解db/db小鼠海马齿状回中神经发生的抑制。提示川橘干燥果皮粉在大脑中发挥抗炎和神经保护作用。
