Rana Divya, Kumar Ajay, Sharma Saurabh
Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, India.
Department of Pharmaceutical Analysis, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, India.
Curr Stem Cell Res Ther. 2018;13(6):438-446. doi: 10.2174/1574888X13666180502100620.
Endothelial progenitor cells are circulating blood cells derived from various sources like bone marrow, spleen, umbilical cord, liver, kidney and other sources that play a vital role in the regeneration of the endothelial lining of blood vessels and wound repair. There are two types of EPCs, early EPCs and late EPCs. EPCs are believed to originate from hematopoietic stem cells and mesenchymal stem cells. The mobilization of progenitor cells from bone marrow to the peripheral circulation is highly regulated under both normal physiological conditions and stress. EPCs contribute to neovascularization and tissue repair in the musculoskeletal, neural tissues and the bone which are mobilized and recruited to the injured tissue. Cell-based therapies of endothelial progenitor cells are time-consuming and expensive for performing in-vitro cell expansion procedures. New therapeutic approaches are being developed using animal models based on the specific functions of EPC in and experiments which have revealed the importance of various signalling pathways. It has been clear that the activation state of EPCs is critical to the vessel repair process and the role has not been completely understood.
内皮祖细胞是来源于骨髓、脾脏、脐带、肝脏、肾脏等多种来源的循环血细胞，在血管内皮再生和伤口修复中发挥着至关重要的作用。内皮祖细胞有两种类型，即早期内皮祖细胞和晚期内皮祖细胞。内皮祖细胞被认为起源于造血干细胞和间充质干细胞。在正常生理条件和应激状态下，祖细胞从骨髓向外周循环的动员都受到高度调节。内皮祖细胞有助于肌肉骨骼、神经组织和骨骼中的新血管形成和组织修复，它们被动员并募集到受损组织。基于内皮祖细胞的细胞疗法在进行体外细胞扩增程序时既耗时又昂贵。基于内皮祖细胞在实验和实验中的特定功能，正在利用动物模型开发新的治疗方法，这些实验揭示了各种信号通路的重要性。很明显，内皮祖细胞的激活状态对血管修复过程至关重要，但其作用尚未完全被理解。
