Bostanci M S, Bakacak M, Kizilkale Yildirim O, Yildirim G, Attar R, Özkan F, Inanc Tolun F
Clin Exp Obstet Gynecol. 2016;43(4):529-533.
To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats.
Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats.
All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm³ and after treatment the volumes dropped to 28.9 ± 14.9 mm3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9±1.4 mm³ and in Group 1, 118.9 ± 20.0 mm3 (p = 0.001). Likewise, similar changes were observed in the histopatological scores.
The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.
评估芦荟凝胶对大鼠手术诱导的子宫内膜异位病灶的预防和减轻作用。
使用24只生殖年龄的未孕、未育雌性Sprague-Dawley白化大鼠。将大鼠随机分为三组（第1组：对照组，第2组：芦荟致子宫内膜异位组，第3组：芦荟治疗子宫内膜异位组）。在所有手术中均采用1毫升生理盐水进行腹腔灌洗，以测定超氧化物歧化酶（SOD）、丙二醛（MDA）和过氧化氢酶（CAT）。24只大鼠共植入48个角。
植入后所有植入物均正常形成。在第3组中，应用芦荟前，体积总和为87.2±20.4立方毫米，治疗后体积降至28.9±14.9立方毫米（p = 0.01）。作为对第2组第二次手术中芦荟对子宫内膜异位形成的评估，体积总和为2.9±1.4立方毫米，而第1组为118.9±20.0立方毫米（p = 0.001）。同样，在组织病理学评分中也观察到了类似变化。
芦荟的应用可提高腹腔液中的抗氧化水平，并降低氧化应激标志物。芦荟对抑制子宫内膜异位病变的形成和消退有效。
