Altincik Ayca, Sönmez Ferah, Yenisey Cigdem, Duman Soner, Can Ayse, Akev Nuriye, Kirdar Sevin, Sezak Murat
Departments of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Division of Pediatric Nephrology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Indian J Pharmacol. 2014 May-Jun;46(3):322-7. doi: 10.4103/0253-7613.132184.
The aim of this study was to investigate the antibacterial, anti-inflammatory, and antioxidant activities and probable toxic effects of Aloe vera (AV) in a rat peritonitis model.
RATS WERE DIVIDED INTO FIVE GROUPS: (1) Control group, (2) AV group, (3) peritonitis group (P), (4) peritonitis + AV group (P + AV), and (5) peritonitis + antibiotherapy group (P + Ab). Ultrafiltration (UF) rates were determined and colony and leukocyte counts were calculated in the dialysate. Glucose, blood urea nitrogen (BUN), creatinine levels, and alanine transaminase (ALT) activities were studied in blood. Glucose, interleukins (IL-1β, IL-6), and prostaglandin E2 (PGE2) were studied in dialysate and peritoneal tissue for the assessment of the anti-inflammatory effect. Copper/zinc superoxide dismutase (Cu, Zn-SOD), malondialdehyde (MDA), and nitric oxide (NO) were also investigated in peritoneal tissue.
Aloe vera increased the UF rate and lowered leukocyte numbers in the peritonitis group. There was no significant difference in blood and dialysate glucose, BUN, creatinine levels and ALT activity among control and AV groups. AV decreased IL-1β, IL-6 and PGE2 in peritonitis, showing good anti-inflammatory effect. AV showed antioxidant effect on the chosen antioxidant parameters Cu, Zn-SOD, MDA, and NO.
It was concluded that, AV might be used in peritonitis for its probable UF increasing, anti-inflammatory, and antioxidant effects.
本研究旨在探讨库拉索芦荟（AV）在大鼠腹膜炎模型中的抗菌、抗炎和抗氧化活性以及可能的毒性作用。
将大鼠分为五组：（1）对照组，（2）AV组，（3）腹膜炎组（P），（4）腹膜炎+AV组（P+AV），以及（5）腹膜炎+抗生素治疗组（P+Ab）。测定超滤（UF）率，并计算透析液中的菌落和白细胞计数。研究血液中的葡萄糖、血尿素氮（BUN）、肌酐水平和丙氨酸转氨酶（ALT）活性。研究透析液和腹膜组织中的葡萄糖、白细胞介素（IL-1β、IL-6）和前列腺素E2（PGE2），以评估抗炎效果。还研究了腹膜组织中的铜/锌超氧化物歧化酶（Cu,Zn-SOD）、丙二醛（MDA）和一氧化氮（NO）。
库拉索芦荟增加了腹膜炎组的超滤率并降低了白细胞数量。对照组和AV组之间的血液和透析液葡萄糖、BUN、肌酐水平及ALT活性无显著差异。AV降低了腹膜炎中的IL-1β、IL-6和PGE2，显示出良好的抗炎效果。AV对所选的抗氧化参数Cu,Zn-SOD、MDA和NO显示出抗氧化作用。
得出的结论是，库拉索芦荟可能因其增加超滤、抗炎和抗氧化作用而可用于腹膜炎。
