某三级医疗中心关于缺铁与注意力缺陷多动障碍相关性的研究。
A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center.
作者信息
Islam Kamirul, Seth Soutrik, Saha Suman, Roy Atanu, Das Rajib, Datta Asok Kumar
机构信息
Department of Pediatrics, Burdwan Medical College, Burdwan, West Bengal, India.
出版信息
Indian J Psychiatry. 2018 Jan-Mar;60(1):131-134. doi: 10.4103/psychiatry.IndianJPsychiatry_197_17.
BACKGROUND
Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD).
AIMS
As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.
SETTINGS AND DESIGN
Hospital-based cross-sectional study.
MATERIALS AND METHODS
Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.
STATISTICAL ANALYSIS
Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. < 0.01 was taken as statistically significant.
RESULTS
Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.
CONCLUSION
Iron deficiency was associated with ADHD.
背景
铁对大脑发育和认知功能很重要。缺铁可能导致神经递质改变，并可能表现为包括注意力缺陷多动障碍（ADHD）在内的不同中枢神经系统疾病。
目的
由于印度背景下的研究较少，我们进行了这项研究以找出缺铁与ADHD之间的关联。
设置与设计
基于医院的横断面研究。
材料与方法
在通过完全枚举法选取的119例ADHD患者和119例对照中，测量了表明铁状态的血液学参数（血红蛋白[Hb]、铁蛋白、铁、总铁结合力[TIBC]、平均红细胞体积[MCV]和平均红细胞血红蛋白含量[MCH]）。
统计分析
采用夏皮罗-威尔克检验、曼-惠特尼U检验、斯皮尔曼相关性分析和二元逻辑回归。P<0.01被视为具有统计学意义。
结果
病例组的Hb、铁、铁蛋白、MCV和MCH较低，且与ADHD呈负相关，而TIBC与ADHD的关系则相反。缺铁性贫血使患ADHD的可能性增加3.82倍。
结论
缺铁与ADHD有关。
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