[磁共振敏感性加权成像在肝细胞癌分级中的诊断效能]

[Diagnostic Performance of Susceptibility-weighted Imaging in the Grading of Hepatocellular Carcinoma].

作者信息

Duan Ting, Chen Jie, Xia Chun-Chao, Song Bin

机构信息

Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Mar;49(2):248-251.

PMID:29737070

Abstract

OBJECTIVE

To test the capability of intratumoral susceptibility signal intensity (ITSS) in the differentiation of hepatocellular carcinoma (HCC) grades.

METHODS

Retrospective reviews of 53 patients with pathologically proven HCCs were performed. All patients underwent both conventional MRI and SWI examinations. The morphological score of ITSS and the number of ITSS per square centimeter were calculated,then compared among low-grade and high-grade HCCs. Spearman correlation coefficients were determined between the morphological scores of ITSS,the number of ITSS per square centimeter and HCC grades. Receiver operating characteristic (ROC) curve analysiss was performed to determine the diagnostic accuracy for HCC differentiation.

RESULTS

The morphological scores of ITSS and the number of ITSS per square centimeter in low-grade HCCs were significantly lower than that in the high-grade HCCs (<0.05). Spearman correlation coefficient between morphological scores of ITSS and HCC grade was 0.54 (<0.01),and that between the number of ITSS per square centimeter and HCC grade was 0.38 (<0.01). In the ROC curve analysis of morphological scores,the AUC was 0.81 (<0.01) and the optimal sensitivity and specificity were 76%,and 88% respectively with a cut-off of 2. In the ROC curve analysis of the number of ITSS per square centimeter,the area under curve () was 0.70 (=0.01) and the optimal sensitivity and specificity were 65%,and 79% respectively with a cut-off of 0.58.

CONCLUSION

ITSS of SWI had the potential to differentiate HCC grades.

摘要

目的

检测肿瘤内易感性信号强度（ITSS）在肝细胞癌（HCC）分级鉴别中的能力。

方法

对53例经病理证实的HCC患者进行回顾性研究。所有患者均接受常规MRI和SWI检查。计算ITSS的形态学评分及每平方厘米ITSS的数量，然后在低级别和高级别HCC之间进行比较。确定ITSS形态学评分、每平方厘米ITSS数量与HCC分级之间的Spearman相关系数。进行受试者操作特征（ROC）曲线分析以确定HCC分级鉴别的诊断准确性。

结果

低级别HCC的ITSS形态学评分及每平方厘米ITSS数量均显著低于高级别HCC（<0.05）。ITSS形态学评分与HCC分级之间的Spearman相关系数为0.54（<0.01），每平方厘米ITSS数量与HCC分级之间的Spearman相关系数为0.38（<0.01）。在ITSS形态学评分的ROC曲线分析中，曲线下面积（AUC）为0.81（<0.01），最佳敏感性和特异性分别为76%和88%，截断值为2。在每平方厘米ITSS数量的ROC曲线分析中，曲线下面积（AUC）为0.70（=0.01），最佳敏感性和特异性分别为65%和79%，截断值为0.58。