State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics , Peking University Shenzhen Graduate School , Shenzhen 518055 , China.
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), and Peking-Tsinghua Center for Life Sciences , Peking University , Beijing 100871 , China.
Org Lett. 2018 May 18;20(10):2876-2879. doi: 10.1021/acs.orglett.8b00903. Epub 2018 May 9.
A convenient approach to the construction of the 5-6-7 tricarbocyclic fused core structure of cyanthiwigins via a Co-mediated Pauson-Khand reaction as a key step has been developed. The cyathane core intermediate obtained by this strategy was used in the concise synthesis of (±)-5- epi-cyanthiwigin I. The developed chemistry paves the way for the total synthesis of structurally diverse cyanthiwigins.
一种通过 Co 介导的 Pauson-Khand 反应构建 5-6-7 三元稠合环核心结构的简便方法已被开发出来，该方法作为关键步骤。通过该策略获得的环番烷核心中间体被用于简洁合成（±）-5-表-环番烷 I。所开发的化学为结构多样的环番烷类化合物的全合成铺平了道路。
