Andrés V, Carreras J, Cussó R
Unitat de Bioquimica, Facultat de Medicina, Universitat de Barcelona, Spain.
Biochem Biophys Res Commun. 1988 Dec 15;157(2):664-9. doi: 10.1016/s0006-291x(88)80301-2.
Citrate, ATP and AMP affect similarly the activation of muscle phosphofructokinase by alpha-glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, but they affect differently its activation by fructose 2,6-bisphosphate. Activation by alpha-glucose 1,6-bisphosphate and fructose 2,6-bisphosphate is also differently affected by pH. This suggest that both alpha-glucose 1,6-bisphosphate and fructose 1,6-bisphosphate induce the same conformational change on muscle phosphofructokinase, distinct from that produced by fructose 2,6-bisphosphate.
柠檬酸、ATP和AMP对α-葡萄糖1,6-二磷酸和果糖1,6-二磷酸激活肌肉磷酸果糖激酶的作用相似，但它们对果糖2,6-二磷酸激活该酶的作用不同。α-葡萄糖1,6-二磷酸和果糖2,6-二磷酸的激活作用受pH的影响也不同。这表明α-葡萄糖1,6-二磷酸和果糖1,6-二磷酸在肌肉磷酸果糖激酶上诱导相同的构象变化，与果糖2,6-二磷酸产生的构象变化不同。
