Rahimi-Esboei Bahman, Zarei Mohammad, Mohebali Mehdi, Valian Hossein Keshavarz, Shojaee Saeedeh, Mahmoudzadeh Raziyeh, Salabati Mirataollah
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Korean J Parasitol. 2018 Apr;56(2):147-152. doi: 10.3347/kjp.2018.56.2.147. Epub 2018 Apr 30.
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti- IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti- IgG, and 8 cases were positive for anti- IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6.8% and 9.4% of cases were positive for IgM and IgG avidity tests, respectively (=0.632). Agreement (Kappa value) between paired tests IgG-IgM, IgG-IgG avidity, and IgM-IgG avidity was 0.080, 0.099, and 0.721, respectively (<0.05). This study showed that conventional serologic tests (IgM and IgG levels) and IgG avidity correlate well each other and can be used to differentiate recent infections from old OT. It seems that reactivated old infections rather than recently acquired infections are majority of Iranian OT patients.
本前瞻性研究旨在通过比较抗IgM和IgG抗体水平以及IgG亲和力试验来检测急性和慢性眼弓形虫病。本研究纳入了117例转诊至伊朗德黑兰法拉比眼科医院的眼弓形虫病（OT）患者。其中，77例抗IgG呈阳性，8例抗IgM呈阳性。IgG亲和力试验显示，分别有11例、4例和102例为低亲和力、中等亲和力和高亲和力，IgM和IgG亲和力试验阳性的病例分别为6.8%和9.4%（=0.632）。配对试验IgG-IgM、IgG-IgG亲和力和IgM-IgG亲和力之间的一致性（Kappa值）分别为0.080、0.099和0.721（<0.05）。本研究表明，传统血清学检测（IgM和IgG水平）与IgG亲和力之间具有良好的相关性，可用于区分近期感染和陈旧性OT。似乎伊朗OT患者中大多数是陈旧感染复发而非近期获得性感染。
