1 Rush University, Chicago, IL, USA.
J Aging Health. 2019 Aug;31(7):1278-1296. doi: 10.1177/0898264318772983. Epub 2018 May 9.
This study examines the effect of antidepressant medication use and social engagement on the level of depressive symptoms at the time of initially meeting criteria for dementia. Measures of social engagement, medication use, and depressive symptoms from 402 participants with incident dementia were utilized for the study. Proportional odds models adjusted for demographics were constructed with depressive symptoms as the outcome and social network size, perceived social isolation, and antidepressant medication use as independent variables. Each additional person in the social network was associated with a lower depressive symptom score, odds ratio (OR) = 0.93, 95% confidence interval (CI) = [0.90, 0.97], ≤ .01, and each unit increase in perceived social isolation was associated with a higher depressive symptom score (OR = 4.14, 95% CI = [2.94, 5.85], ≤ .01). No association was found between antidepressant medication use and depressive symptom score. Depression management at the time of dementia diagnosis should probably be directed toward increasing social engagement in older adults.
这项研究考察了抗抑郁药物的使用和社会参与度对符合痴呆症诊断标准时抑郁症状严重程度的影响。该研究使用了 402 名新发痴呆症患者的社会参与度、药物使用和抑郁症状测量数据。构建了比例优势模型，以抑郁症状为因变量，社会网络规模、感知社交孤立和抗抑郁药物使用为自变量，并进行了人口统计学调整。社会网络中每增加一个人，抑郁症状评分就会降低（OR = 0.93，95%CI [0.90, 0.97]，≤0.01），感知社交孤立每增加一个单位，抑郁症状评分就会升高（OR = 4.14，95%CI [2.94, 5.85]，≤0.01）。抗抑郁药物的使用与抑郁症状评分之间没有关联。在痴呆症诊断时，可能应该将抑郁管理的重点放在增加老年人的社会参与度上。
