Department of Health Statistics, School of Public Health, Dalian Medical University, Dalian, China.
The Physical Examination Centre, The Physical Examination Centre of the Second Affiliated Hospital to Dalian Medical University, Dalian, Liaoning, China.
BMJ Open. 2018 May 9;8(5):e018659. doi: 10.1136/bmjopen-2017-018659.
Currently, most studies only reveal the relationship between baseline high-density lipoprotein cholesterol (HDL-c) or low-density lipoprotein cholesterol (LDL-c) levels and metabolic syndrome (MetS). The relationship between dynamic changes in HDL-c or LDL-c and MetS remains unclear. We aimed to gain a deeper understanding of the relationship between the dynamic changes in HDL-c or LDL-c and MetS.
A prospective study.
The Medical Centre of the Second Hospital affiliated with Dalian Medical University from 2010 to 2016.
A total of 4542 individuals who were initially MetS-free and completed at least two follow-up examinations as part of the longitudinal population were included.
The Joint Interim Statement criteria 2009 were used to define MetS. We used the Joint model to estimate the relative risks (RRs) of incident MetS.
The cumulative incidence of MetS was 17.81% and was 14.86% in men and 5.36% in women during the 7 years of follow-up. In the Joint models, the RRs of the longitudinal decrease in HDL-c and the longitudinal increase in LDL-c for the development of MetS were 18.8781-fold (95% CI 12.5156 to 28.4900) and 1.3929-fold (95% CI 1.2283 to 1.5795), respectively.
The results highlight that the dynamic longitudinal decrement of HDL-c or the increment of LDL-c is associated with an elevated risk of MetS.
目前，大多数研究仅揭示了基线高密度脂蛋白胆固醇（HDL-c）或低密度脂蛋白胆固醇（LDL-c）水平与代谢综合征（MetS）之间的关系。HDL-c 或 LDL-c 动态变化与 MetS 之间的关系尚不清楚。我们旨在更深入地了解 HDL-c 或 LDL-c 动态变化与 MetS 之间的关系。
前瞻性研究。
2010 年至 2016 年期间，大连医科大学附属第二医院医疗中心。
共纳入 4542 名最初无 MetS 且至少完成两次随访检查的个体作为纵向人群。
采用 2009 年联合临时声明标准定义 MetS。我们使用联合模型估计发生 MetS 的相对风险（RR）。
在 7 年的随访期间，MetS 的累积发病率为 17.81%，男性为 14.86%，女性为 5.36%。在联合模型中，HDL-c 纵向下降和 LDL-c 纵向升高与 MetS 发生的 RR 分别为 18.8781 倍（95%CI 12.5156 至 28.4900）和 1.3929 倍（95%CI 1.2283 至 1.5795）。
结果表明，HDL-c 的纵向下降或 LDL-c 的增加与 MetS 的风险增加相关。
