The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, 518060, China.
Adv Healthc Mater. 2018 Jul;7(14):e1800296. doi: 10.1002/adhm.201800296. Epub 2018 May 10.
Nanomedicine has significantly impacted cancer theranostics. However, its efficiency is restricted by the limited enhanced permeability and retention effect of nanomaterials and insufficient density/specificity of receptors of tumor cells. Herein, an apoptosis-homing nanoplatform based on zinc(II) dipicolylamine (ZnDPA) conjugated Fe/Fe O nanoparticles (MNPs/ZnDPA), which demonstrates amplified magnetic resonance signal and photothermal therapy, is developed. In an apoptotic xenograft model constructed by doxorubicin, due to the high affinity between ZnDPA and the upregulated level of phosphatidylserine on the outer surface of apoptotic cancer cells, the accumulation value of MNPs/ZnDPA is enhanced two-fold and the tumor/muscle ratio of T values is decreased to 50% compared to that in the normal xenograft model. In the apoptotic xenograft model, the amplifying photothermal therapy is confirmed by the changes of the relative tumor volume and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling staining. This nanoplatform provides a promising strategy to improve the targeting efficiency of nanoparticles and the enhancement of tumor-targeting theranostics.
纳米医学在癌症治疗诊断中具有重要意义。然而，其效率受到纳米材料增强的通透性和保留效应有限以及肿瘤细胞受体的密度/特异性不足的限制。在此，开发了一种基于锌(II)二吡啶甲酰胺（ZnDPA）偶联的 Fe/FeO 纳米颗粒（MNPs/ZnDPA）的凋亡靶向纳米平台，该平台具有放大的磁共振信号和光热治疗作用。在阿霉素构建的凋亡异种移植模型中，由于 ZnDPA 与凋亡癌细胞外表面上调的磷脂酰丝氨酸之间的高亲和力，MNPs/ZnDPA 的积累值增加了一倍，T 值的肿瘤/肌肉比降低到 50%与正常异种移植模型相比。在凋亡异种移植模型中，相对肿瘤体积和末端脱氧核苷酸转移酶介导的 dUTP-生物素缺口末端标记染色的变化证实了放大的光热治疗。该纳米平台为提高纳米颗粒的靶向效率和增强肿瘤靶向治疗提供了一种有前途的策略。
