The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China.
Department of Chemistry, Fudan University, Shanghai, 200433, China.
Adv Healthc Mater. 2018 May;7(9):e1701201. doi: 10.1002/adhm.201701201. Epub 2018 Jan 22.
Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe O nanoparticles (RGD-PEG-MNPs) are developed for photoacoustic (PA)-enabled self-guidance in tumor-targeting magnetic hyperthermia therapy in vivo. In the α β -positive U87MG glioblastoma xenograft model, the PA signal of RGD-PEG-MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2-folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD-PEG-MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD-PEG-MNPs.
磁性纳米颗粒因其内在的成像和治疗能力的整合而在治疗学中受到广泛关注。在此，我们开发了一种 c(RGDyK) 肽聚乙二醇化 Fe@Fe3O4 纳米颗粒 (RGD-PEG-MNPs)，用于在体内肿瘤靶向磁热疗中实现光声 (PA) 引导的自我导向。在 αβ-阳性 U87MG 神经胶质瘤异种移植模型中，静脉注射后 6 小时，RGD-PEG-MNPs 的 PA 信号在肿瘤中达到最大值。与预注射相比，该信号增强了 2.2 倍，与阻断组相比也高 2.2 倍。这表明了 RGD-PEG-MNPs 的优异靶向特性。在 PA 的引导下，RGD-PEG-MNPs 实现了对肿瘤的有效磁热疗。
