Jia Rongxi, Ma Yunfei, Gu Zhaoyong, Pan Youlian, Liu Sicong, Qiao Aike, Guo Chao, Dong Nianguo, Li Xiaofeng, Liu Yinglong
College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P.R.China.
College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124,
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Jun 1;34(3):365-370. doi: 10.7507/1001-5515.201605021.
The aim of the present experimental study is to determine the effects of sinotubular junction diameter on artificial bioprosthesis valves. An experimental study was performed for aortic root models with different sinotubular junction taper under pulsatile flow condition. The sinotubular junction diameters were modified to create four models with different sinotubular junction tapers with 0, 1, 3 and 5 degrees, respectively, using three dimensional printing techniques. After installing the testing bioprosthesis valve on the aortic root models, we conducted experiments of the pulsatile flow testing with different stroke volume in the pulsatile circulation simulation system. The testing condition was set at the pulse frequency of 70 beats/min and the stroke volume of 2-7 L/min. The status of the valves in 10 continuous pulse cycles was tested and the average results were obtained for each stroke volume. The results of testing showed that the mean transvalvular pressure gradients agreed well with the national standard, and all smaller than 10 mm Hg. The sinotubular junction taper had an influence on regurgitation fraction of the artificial bioprosthesis valve. The smaller sinotubular junction taper showed beneficial effect to decrease the regurgitation fraction. In the case of smaller stroke volume, the smaller sinotubular junction taper was beneficial to increase the effective valve orifice area. In the case of larger stroke volume, the larger sinotubular junction taper was beneficial to increase the effective valve orifice area. This study indicates that a doctor should consider the smaller sinotubular junction taper in the case of smaller stroke volume more. In the case of larger stroke volume, the doctor should consider the larger sinotubular junction taper more.
本实验研究的目的是确定窦管交界直径对人工生物瓣膜的影响。在脉动流条件下，对具有不同窦管交界锥度的主动脉根部模型进行了实验研究。利用三维打印技术，将窦管交界直径进行修改，创建了四个具有不同窦管交界锥度的模型，锥度分别为0度、1度、3度和5度。在主动脉根部模型上安装测试生物瓣膜后，我们在脉动循环模拟系统中进行了不同搏出量的脉动流测试实验。测试条件设定为脉搏频率70次/分钟，搏出量2 - 7升/分钟。对10个连续脉搏周期内瓣膜的状态进行测试，并获得每个搏出量的平均结果。测试结果表明，平均跨瓣压差与国家标准吻合良好，且均小于10毫米汞柱。窦管交界锥度对人工生物瓣膜的反流分数有影响。较小的窦管交界锥度对降低反流分数有有益作用。在较小搏出量的情况下，较小的窦管交界锥度有利于增加有效瓣口面积。在较大搏出量的情况下，较大的窦管交界锥度有利于增加有效瓣口面积。本研究表明，在较小搏出量的情况下，医生应更多地考虑较小的窦管交界锥度。在较大搏出量的情况下，医生应更多地考虑较大的窦管交界锥度。
