Luzum Jasmine A, Luzum Matthew J
Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, 5084 Graves Hall, 333 W 10th Ave., Columbus, OH 43210, USA.
Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Per Med. 2016 Mar;13(2):119-127. doi: 10.2217/pme.15.57. Epub 2016 Mar 1.
Our aim was to evaluate physicians' attitudes toward pharmacogenetic testing before and after pharmacogenetic education.
In total, 12 physicians (˜40% response rate) completed a survey with eight questions on 10-point scales on their attitudes toward pharmacogenetic testing before and after a 1-h grand rounds presentation on pharmacogenetics. Differences in question scores overall, among training levels (resident/fellow/attending), and specific drugs (clopidogrel/simvastatin/warfarin) were assessed using Wilcoxon signed-rank and exact Kruskal-Wallis tests.
RESULTS & CONCLUSION: The scores for all eight questions increased, with statistically significant (p < 0.05) increases for four out of eight questions. The scores were similar among training levels, but the postscores for clopidogrel were significantly higher than for simvastatin and warfarin. In conclusion, brief pharmacogenetic education can significantly affect physicians' attitudes toward pharmacogenetic testing.
我们的目的是评估医生在接受药物遗传学教育前后对药物遗传学检测的态度。
共有12名医生（回复率约40%）完成了一项调查，该调查包含八个问题，采用10分制衡量他们在接受1小时关于药物遗传学的大查房报告前后对药物遗传学检测的态度。使用Wilcoxon符号秩检验和精确Kruskal-Wallis检验评估总体问题得分、培训水平（住院医师/研究员/主治医师）之间以及特定药物（氯吡格雷/辛伐他汀/华法林）之间的差异。
所有八个问题的得分均有所提高，其中八个问题中有四个得分的提高具有统计学意义（p < 0.05）。不同培训水平的得分相似，但氯吡格雷的课后得分显著高于辛伐他汀和华法林。总之，简短的药物遗传学教育可显著影响医生对药物遗传学检测的态度。
