D1和D2拮抗剂对小鼠和大鼠基础体温以及阿扑吗啡所致体温降低的影响。

Effects of D1 and D2 antagonists on basal and apomorphine decreased body temperature in mice and rats.

作者信息

Chipkin R E

机构信息

Department of Pharmacology, Schering-Plough Corporation, Bloomfield, NJ 07003.

出版信息

Pharmacol Biochem Behav. 1988 Jul;30(3):683-6. doi: 10.1016/0091-3057(88)90084-6.

DOI:10.1016/0091-3057(88)90084-6

PMID:2974995

Abstract

In these experiments representative selective antagonists at D1 (SCH 23390) and D2 (haloperidol) receptors were studied for their effects on basal and apomorphine decreased body temperature in mice and rats. In mice, SCH 23390 (up to 3 mg/kg SC) neither affected basal body temperature nor blocked apomorphine-induced hypothermia (AIH). On the other hand, haloperidol alone was hypothermic and paradoxically also blocked AIH in mice. In rats, SCH 23390 alone produced hyperthermia; the mechanism by which this occurred is not known. SCH 23390 also blocked AIH in rats. However, the inhibition of AIH only occurred at doses of SCH 23390 that were themselves hyperthermic. Haloperidol did not alter basal body temperature but did block AIH in rats. These data suggest that apomorphine-induced body temperature changes are D2 mediated.

摘要

在这些实验中，研究了D1受体（SCH 23390）和D2受体（氟哌啶醇）的代表性选择性拮抗剂对小鼠和大鼠基础体温以及阿扑吗啡降低体温的影响。在小鼠中，SCH 23390（皮下注射剂量高达3 mg/kg）既不影响基础体温，也不阻断阿扑吗啡诱导的体温过低（AIH）。另一方面，单独使用氟哌啶醇会导致体温过低，且反常的是它也能阻断小鼠的AIH。在大鼠中，单独使用SCH 23390会引起体温过高；其发生机制尚不清楚。SCH 23390也能阻断大鼠的AIH。然而，仅在SCH 23390本身能引起体温过高的剂量下才会抑制AIH。氟哌啶醇不会改变基础体温，但能阻断大鼠的AIH。这些数据表明，阿扑吗啡诱导的体温变化是由D2介导的。