Harata Daichi, Tsuchiya Yuya, Miyoshi Tomoyuki, Yanai Tokuma, Suzuki Kazuhiko, Murakami Tomoaki
Laboratory of Veterinary Toxicology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Nagaragawa Research Center, API Co., Ltd., 692-3 Nagara, Gifu-shi, Gifu 502-0071, Japan.
J Toxicol Pathol. 2018 Apr;31(2):89-93. doi: 10.1293/tox.2017-0044. Epub 2017 Dec 24.
In the several types of amyloidoses, participation of oxidative stresses in the pathogenesis and the effect of antioxidants on amyloidosis have been reported. Meanwhile, the relationship between oxidative stresses and pathogenesis of amyloid A (AA) amyloidosis is still unclear. In this study, we used an antioxidant, Brazilian propolis, to investigate the inhibitory effects on AA amyloidosis. The results showed that AA deposition was inhibited by administration of propolis. Increased expression of antioxidant markers was detected in molecular biological examinations of mice treated with propolis. Although serum amyloid A (SAA) levels were strongly correlated with the immunoreactive area of AA deposits in the control group, the correlation was weaker in the propolis-treated groups. In addition, there were no changes in SAA levels between the control group and the propolis-treated groups. The results indicate that propolis, an antioxidant, may induce inhibitory effects against AA amyloidosis.
在几种类型的淀粉样变性中，已经报道了氧化应激在发病机制中的参与以及抗氧化剂对淀粉样变性的影响。同时，氧化应激与淀粉样A（AA）淀粉样变性发病机制之间的关系仍不清楚。在本研究中，我们使用一种抗氧化剂巴西蜂胶来研究其对AA淀粉样变性的抑制作用。结果表明，给予蜂胶可抑制AA沉积。在用蜂胶处理的小鼠的分子生物学检查中检测到抗氧化标志物的表达增加。虽然在对照组中血清淀粉样A（SAA）水平与AA沉积物的免疫反应面积密切相关，但在蜂胶处理组中这种相关性较弱。此外，对照组和蜂胶处理组之间的SAA水平没有变化。结果表明，抗氧化剂蜂胶可能对AA淀粉样变性具有抑制作用。
