J Am Pharm Assoc (2003). 2018 Jul-Aug;58(4):377-381. doi: 10.1016/j.japh.2018.04.011. Epub 2018 May 8.
To discuss the potential for improving access to early abortion care through pharmacies in the United States.
Despite the growing use of medications to induce termination of early pregnancy, pharmacist involvement in abortion care is currently limited. The Food and Drug Administration's Risk Evaluation and Mitigation Strategy (REMS) for Mifeprex® (mifepristone 200 mg), the principal drug used in early medication abortion, prohibits the dispensing of the drug by prescription at pharmacies. This commentary reviews the pharmacology of medication abortion with the use of mifepristone and misoprostol, as well as aspects of service delivery and data on safety, efficacy, and acceptability. Given its safety record, mifepristone no longer fits the profile of a drug that requires an REMS. The recent implementation of pharmacy dispensing of mifepristone in community pharmacies in Australia and some provinces of Canada has improved access to medication abortion by increasing the number of medication abortion providers, particularly in rural areas.
Provision of mifepristone in pharmacies, which involves dispensing and patient counseling, would likely improve access to early abortion in the United States without increasing risks to women.
讨论在美国通过药店提高早期堕胎护理可及性的潜力。
尽管越来越多地使用药物来终止早期妊娠,但药剂师在堕胎护理中的参与目前受到限制。米非司酮(米非司酮 200 毫克)的主要药物,用于早期药物流产的 FDA 风险评估和缓解策略(REMS)禁止在药店凭处方分发该药物。本评论审查了米非司酮和米索前列醇药物流产的药理学,以及服务提供和安全性、疗效和可接受性方面的数据。鉴于其安全记录,米非司酮不再符合需要 REMS 的药物特征。最近在澳大利亚的社区药店和加拿大的一些省份实施的米非司酮药房配发,通过增加药物流产提供者的数量,特别是在农村地区,改善了药物流产的可及性。
在药店提供米非司酮,包括配药和患者咨询,可能会在美国提高早期堕胎的可及性,而不会增加妇女的风险。