Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
Front Immunol. 2018 Apr 27;9:941. doi: 10.3389/fimmu.2018.00941. eCollection 2018.
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD.
移植物抗宿主病，无论是急性还是慢性（aGvHD，cGvHD），在接受造血细胞移植（HCT）的患者中仍然是一个主要并发症，也是一个重大的治疗挑战，因为许多患者对目前可用的治疗方法反应不足。由于越来越多的抗菌药物耐药性，人们对使用细菌病毒（噬菌体）来对抗抗生素耐药菌重新产生了极大的兴趣。近年来，有证据表明噬菌体还具有抗炎和免疫调节作用。本文提出了噬菌体的这些抗细菌和免疫调节作用如何转化为急性 GvHD 的新治疗方法。
