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光学激发发光剂量计在钴-60高剂量率近距离放射治疗系统中的剂量学特性

Dosimetric characterisation of the optically-stimulated luminescence dosimeter in cobalt-60 high dose rate brachytherapy system.

作者信息

Rejab M, Wong J H D, Jamalludin Z, Jong W L, Malik R A, Wan Ishak W Z, Ung N M

机构信息

Clinical Oncology Unit, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Australas Phys Eng Sci Med. 2018 Jun;41(2):475-485. doi: 10.1007/s13246-018-0647-6. Epub 2018 May 13.

Abstract

This study investigates the characteristics and application of the optically-stimulated luminescence dosimeter (OSLD) in cobalt-60 high dose rate (HDR) brachytherapy, and compares the results with the dosage produced by the treatment planning system (TPS). The OSLD characteristics comprised linearity, reproducibility, angular dependence, depth dependence, signal depletion, bleaching rate and cumulative dose measurement. A phantom verification exercise was also conducted using the Farmer ionisation chamber and in vivo diodes. The OSLD signal indicated a supralinear response (R = 0.9998). It exhibited a depth-independent trend after a steep dose gradient region. The signal depletion per readout was negligible (0.02%), with expected deviation for angular dependence due to off-axis sensitive volume, ranging from 1 to 16%. The residual signal of the OSLDs after 1 day bleached was within 1.5%. The accumulated and bleached OSLD signals had a standard deviation of ± 0.78 and ± 0.18 Gy, respectively. The TPS was found to underestimate the measured doses with deviations of 5% in OSLD, 17% in the Farmer ionisation chamber, and 7 and 8% for bladder and rectal diode probes. Discrepancies can be due to the positional uncertainty in the high-dose gradient. This demonstrates a slight displacement of the organ at risk near the steep dose gradient region will result in a large dose uncertainty. This justifies the importance of in vivo measurements in cobalt-60 HDR brachytherapy.

摘要

本研究调查了光激励发光剂量仪(OSLD)在钴 - 60高剂量率(HDR)近距离治疗中的特性及应用,并将结果与治疗计划系统(TPS)生成的剂量进行比较。OSLD的特性包括线性、可重复性、角度依赖性、深度依赖性、信号损耗、漂白率和累积剂量测量。还使用 Farmer 电离室和体内二极管进行了模体验证实验。OSLD信号显示出超线性响应(R = 0.9998)。在陡峭的剂量梯度区域之后,它呈现出与深度无关的趋势。每次读出的信号损耗可忽略不计(0.02%),由于离轴敏感体积,角度依赖性的预期偏差范围为1%至16%。1天漂白后OSLD的残余信号在1.5%以内。累积和漂白后的OSLD信号的标准偏差分别为±0.78和±0.18 Gy。发现TPS低估了测量剂量,在OSLD中偏差为5%,在Farmer电离室中为17%,膀胱和直肠二极管探头分别为7%和8%。差异可能是由于高剂量梯度中的位置不确定性。这表明在陡峭剂量梯度区域附近,危及器官的轻微位移会导致较大的剂量不确定性。这证明了在钴 - 60 HDR近距离治疗中进行体内测量的重要性。

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