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钯-103永久性乳腺籽源植入近距离放射治疗中皮肤剂量与光激励发光剂量计剂量关系的蒙特卡罗研究

Monte Carlo study of the relationship between skin dose and optically stimulated luminescence dosimeter dose in Pd-103 permanent breast seed implant brachytherapy.

作者信息

Nich Steven, Kirkby Charles, Villarreal-Barajas J Eduardo

机构信息

Department of Physics and Astronomy, University of Calgary, Calgary Alberta, Canada.

Department of Physics and Astronomy, University of Calgary, Calgary Alberta, Canada; Department of Oncology, University of Calgary, Calgary Alberta, Canada; Department of Medical Physics, Jack Ady Cancer Centre, Lethbridge, Alberta, Canada.

出版信息

Brachytherapy. 2019 May-Jun;18(3):387-395. doi: 10.1016/j.brachy.2019.01.008. Epub 2019 Feb 18.

Abstract

PURPOSE

To establish a method for estimating skin dose for patients with permanent breast seed implant based on in vivo optically stimulated luminescence dosimeters (OSLDs) measurements.

METHODS AND MATERIALS

Monte Carlo simulations were performed in a simple breast phantom using the EGSnrc user code egs_brachy. Realistic models of the IsoAid Advantage Pd-103 brachytherapy source and Landauer nanoDot OSLD were created to model in vivo skin dose measurements where an OSLD would be placed on the skin of a patient with permanent breast seed implant following implantation. Doses to a 0.2 cm volume of skin beneath the OSLD and to the sensitive volume within the OSLD were calculated, and the ratio of these values was found for various seed positions inside the breast phantom. The maximum value of this ratio may be used as a conversion factor that would allow skin dose to be estimated from in vivo OSLD measurements.

RESULTS

Conversion factors of 0.5 and 1.44 are recommended for OSLDs calibrated to dose to AlO and water, respectively, at the point of measurement in the OSLD. These factors were not significantly affected by the addition of extra seeds in the dose calculations.

CONCLUSIONS

A method for estimating skin dose from OSLD measurements was proposed. Individual institutions should calibrate OSLDs to Pd-103 seeds to apply the results of this work clinically.

摘要

目的

基于体内光激发发光剂量计(OSLD)测量结果,建立一种估算永久性乳腺籽源植入患者皮肤剂量的方法。

方法与材料

使用EGSnrc用户代码egs_brachy在一个简单的乳腺体模中进行蒙特卡罗模拟。创建了IsoAid Advantage Pd - 103近距离治疗源和Landauer nanoDot OSLD的真实模型,以模拟体内皮肤剂量测量,即植入永久性乳腺籽源后将OSLD放置在患者皮肤上的情况。计算了OSLD下方0.2 cm皮肤体积的剂量以及OSLD内敏感体积的剂量,并针对乳腺体模内不同籽源位置求出这些值的比值。该比值的最大值可作为一个转换因子,用于根据体内OSLD测量结果估算皮肤剂量。

结果

对于在OSLD测量点分别校准到对AlO和水的剂量的OSLD,建议的转换因子分别为0.5和1.44。在剂量计算中添加额外的籽源对这些因子没有显著影响。

结论

提出了一种根据OSLD测量结果估算皮肤剂量的方法。各机构应将OSLD校准到Pd - 103籽源,以便在临床上应用本研究结果。

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