N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991.
Institute of Biomedical Chemistry, Moscow, Russia, 119991.
Appl Microbiol Biotechnol. 2019 Feb;103(4):1627-1642. doi: 10.1007/s00253-018-9560-x. Epub 2019 Jan 8.
Hydroperoxides are a small and interesting group of biologically active natural marine compounds. All these metabolites contain a group (R-O-O-H). In this mini-review, studies of more than 80 hydroperoxides isolated from bacteria, fungi, algae, and marine invertebrates are described. Hydroperoxides from the red, brown, and green algae exhibit high antineoplastic, anti-inflammatory, and antiprotozoal activity with a confidence of 73 to 94%. Hydroperoxides produced by soft corals showed antineoplastic and antiprotozoal activity with confidence from 81 to 92%. Metabolites derived from sea sponges, mollusks, and other invertebrates showed antineoplastic and antiprotozoal (Plasmodium) activity with confidence from 80 to 90%.
过氧化物是一组具有生物活性的小型有趣的天然海洋化合物。所有这些代谢物都含有一个基团（R-O-O-H）。在这篇简要综述中，描述了从细菌、真菌、藻类和海洋无脊椎动物中分离出的 80 多种过氧化物的研究。红藻、褐藻和绿藻中的过氧化物具有高抗肿瘤、抗炎和抗原生动物活性，置信度为 73%至 94%。来自软珊瑚的过氧化物具有抗肿瘤和抗原生动物（疟原虫）活性，置信度为 81%至 92%。来自海海绵、软体动物和其他无脊椎动物的代谢物具有抗肿瘤和抗原生动物（疟原虫）活性，置信度为 80%至 90%。
