新型精神药物卤培米特在大鼠脑中的区域定位。

Regional localization of halopemide, a new psychotropic agent, in the rat brain.

作者信息

Loonen A J, van Wijngaarden I, Janssen P A, Soudijn W

出版信息

Eur J Pharmacol. 1978 Aug 15;50(4):403-8. doi: 10.1016/0014-2999(78)90146-2.

Abstract

Halopemide is a new psychotropic agent, structurally related to the neuroleptics of the butyrophenone type, but with a different phamacological and clinical profile. The concentration of halopemide in the rat brain is about 10 times less than that of R29800, its chemical congener and of spiperone, both typical neuroleptics. In the pituitary gland, however, the levels are the same. The distribution profile of halopemide in rat brain deviates from that of neuroleptics. The highest level of halopemide is found in septal and thalamic areas whereas the neuroleptics are concentrated in the caudate nucleus, the nucleus accumbens and the tuberculum olfactorium. Subcellular distribution experiments show that in the caudate nucleus halopemide is far less particle-bound that are the neuroleptic agents.

摘要

卤培米特是一种新型精神药物，在结构上与丁酰苯类抗精神病药物相关，但具有不同的药理和临床特征。卤培米特在大鼠脑中的浓度比其化学同系物R29800和典型抗精神病药物螺哌隆低约10倍。然而，在垂体中，它们的水平是相同的。卤培米特在大鼠脑中的分布特征与抗精神病药物不同。卤培米特在隔区和丘脑区域的含量最高，而抗精神病药物则集中在尾状核、伏隔核和嗅结节。亚细胞分布实验表明，在尾状核中，卤培米特与颗粒的结合远少于抗精神病药物。