Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan.
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00554-18. Print 2018 Aug.
The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in The , , , and genes were upregulated in response to kanamycin exposure. Of these, and were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance. Inactivation of and compromised protease-mediated intrinsic aminoglycoside resistance and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment of infections.
研究了蛋白酶伴侣系统、SmeYZ 泵和氨基糖苷类耐药性的关联，结果表明，在 、 、 和 基因被上调以响应卡那霉素暴露。其中， 和 是导致固有氨基糖苷（AG）耐药性的主要决定因素。 和 的失活削弱了蛋白酶介导的固有氨基糖苷耐药性，并减弱了 SmeYZ 泵介导的氨基糖苷类耐药性，表明 HtpX 和 ClpA 可能成为治疗 感染的 AG 辅助治疗靶点。
