ClpA 和 HtpX 蛋白酶参与嗜麦芽窄食单胞菌的固有氨基糖苷类耐药性，是潜在的氨基糖苷类药物增效剂靶标。
ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets.
机构信息
Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan.
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
出版信息
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00554-18. Print 2018 Aug.
Abstract
The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in The , , , and genes were upregulated in response to kanamycin exposure. Of these, and were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance. Inactivation of and compromised protease-mediated intrinsic aminoglycoside resistance and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment of infections.
摘要
研究了蛋白酶伴侣系统、SmeYZ 泵和氨基糖苷类耐药性的关联，结果表明，在 、 、 和 基因被上调以响应卡那霉素暴露。其中， 和 是导致固有氨基糖苷（AG）耐药性的主要决定因素。 和 的失活削弱了蛋白酶介导的固有氨基糖苷耐药性，并减弱了 SmeYZ 泵介导的氨基糖苷类耐药性，表明 HtpX 和 ClpA 可能成为治疗 感染的 AG 辅助治疗靶点。
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