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本文引用的文献

1

SmeDEF-mediated antimicrobial drug resistance in Stenotrophomonas maltophilia clinical isolates having defined phylogenetic relationships.嗜麦芽窄食单胞菌临床分离株中SmeDEF介导的抗菌药物耐药性与特定系统发育关系相关。

J Antimicrob Chemother. 2006 Jun;57(6):1070-6. doi: 10.1093/jac/dkl106. Epub 2006 Apr 5.

2

Beta-lactam resistance and beta-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationships.具有明确系统发育关系的临床嗜麦芽窄食单胞菌分离株中的β-内酰胺耐药性和β-内酰胺酶表达

J Antimicrob Chemother. 2006 Feb;57(2):199-203. doi: 10.1093/jac/dki453. Epub 2005 Dec 13.

3

Role of the acetyltransferase AAC(6')-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia.乙酰转移酶AAC(6')-Iz修饰酶在嗜麦芽窄食单胞菌氨基糖苷类耐药中的作用

J Antimicrob Chemother. 2003 Apr;51(4):803-11. doi: 10.1093/jac/dkg148. Epub 2003 Mar 13.

4

Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌中L1和L2β-内酰胺酶表达的差异调节

J Antimicrob Chemother. 2002 Feb;49(2):387-9. doi: 10.1093/jac/49.2.387.

5

Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌L1和L2β-内酰胺酶基因的质粒定位及分子异质性

Antimicrob Agents Chemother. 2001 Feb;45(2):413-9. doi: 10.1128/AAC.45.2.413-419.2001.

6

A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌临床分离株基因组中一个活性Tn1样转座子上编码的TEM-2β-内酰胺酶。

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7

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌染色体aac(6')-Iz基因的特性分析

Antimicrob Agents Chemother. 1999 Oct;43(10):2366-71. doi: 10.1128/AAC.43.10.2366.

8

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.一种用于特异性切除染色体定位DNA序列的广宿主范围Flp-FRT重组系统：在分离无标记铜绿假单胞菌突变体中的应用

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9

Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌相关感染的微生物学及临床方面

Clin Microbiol Rev. 1998 Jan;11(1):57-80. doi: 10.1128/CMR.11.1.57.

10

Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa.铜绿假单胞菌中一个新的染色体氨基糖苷磷酸转移酶基因aph(3')-IIb的序列及特性分析

Antimicrob Agents Chemother. 1996 May;40(5):1254-6. doi: 10.1128/AAC.40.5.1254.

嗜麦芽窄食单胞菌的氨基糖苷类耐药决定因子Aph(3')-IIc

Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.

作者信息

Okazaki Aki, Avison Matthew B

机构信息

Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2007 Jan;51(1):359-60. doi: 10.1128/AAC.00795-06. Epub 2006 Nov 6.

DOI:10.1128/AAC.00795-06

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797691/

Abstract

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

摘要

我们报道了嗜麦芽窄食单胞菌临床分离株K279a中一个内在的、染色体携带的aph(3')-IIc基因的特征，该基因编码一种氨基糖苷磷酸转移酶，当在大肠杆菌中表达时，可显著提高卡那霉素、新霉素、丁胺卡那霉素和巴龙霉素的最低抑菌浓度（MIC）。K279a中aph(3')-IIc基因的缺失导致这些药物的MIC降低。