嗜麦芽窄食单胞菌的氨基糖苷类耐药决定因子Aph(3')-IIc
Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
作者信息
Okazaki Aki, Avison Matthew B
机构信息
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2007 Jan;51(1):359-60. doi: 10.1128/AAC.00795-06. Epub 2006 Nov 6.
Abstract
We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.
摘要
我们报道了嗜麦芽窄食单胞菌临床分离株K279a中一个内在的、染色体携带的aph(3')-IIc基因的特征，该基因编码一种氨基糖苷磷酸转移酶，当在大肠杆菌中表达时，可显著提高卡那霉素、新霉素、丁胺卡那霉素和巴龙霉素的最低抑菌浓度（MIC）。K279a中aph(3')-IIc基因的缺失导致这些药物的MIC降低。
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