Mathiesen Jes Sloth, Kroustrup Jens Peter, Vestergaard Peter, Stochholm Kirstine, Poulsen Per Løgstrup, Rasmussen Åse Krogh, Feldt-Rasmussen Ulla, Schytte Sten, Londero Stefano Christian, Pedersen Henrik Baymler, Hahn Christoffer Holst, Djurhuus Bjarki Ditlev, Bentzen Jens, Möller Sören, Gaustadnes Mette, Rossing Maria, Nielsen Finn Cilius, Brixen Kim, Frederiksen Anja Lisbeth, Godballe Christian
Department of ORL Head & Neck SurgeryOdense University Hospital, Odense, Denmark
Department of Clinical ResearchUniversity of Southern Denmark, Odense, Denmark.
Endocr Connect. 2018 Jun;7(6):829-839. doi: 10.1530/EC-18-0157. Epub 2018 May 14.
Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic medullary thyroid carcinoma (SMTC) and hereditary MTC (HMTC) affect the MTC incidence over time. We conducted a nationwide retrospective study using previously described and MTC cohorts combined with review of medical records, pedigree comparison and relevant nationwide registries. The study included 474 MTC patients diagnosed in Denmark between 1960 and 2014. In the nationwide period from 1997 to 2014, we recorded a mean age-standardized incidence of all MTC, SMTC and HMTC of 0.19, 0.13 and 0.06 per 100,000 per year, respectively. The average annual percentage change in incidence for all MTC, SMTC and HMTC were 1.0 ( = 0.542), 2.8 ( = 0.125) and -3.1 ( = 0.324), respectively. The corresponding figures for point prevalence at January 1, 2015 were 3.8, 2.5 and 1.3 per 100,000, respectively. The average annual percentage change in prevalence from 1998 to 2015 for all MTC, SMTC and HMTC was 2.8 ( < 0.001), 3.8 ( < 0.001) and 1.5 ( = 0.010), respectively. We found no significant change in the incidence of all MTC, SMTC and HMTC possibly due to our small sample size. However, due to an increasing trend in the incidence of all MTC and opposing trends of SMTC (increasing) and HMTC (decreasing) incidence, it seems plausible that an increase for all MTC seen by others may be driven by the SMTC group rather than the HMTC group.
近期研究表明，甲状腺髓样癌（MTC）发病率的时间趋势显著上升。然而，散发性甲状腺髓样癌（SMTC）和遗传性MTC（HMTC）随时间推移对MTC发病率的影响程度仍不清楚。我们进行了一项全国性回顾性研究，使用先前描述的MTC队列，并结合病历审查、家系比较和相关的全国性登记处。该研究纳入了1960年至2014年期间在丹麦诊断出的474例MTC患者。在1997年至2014年的全国范围内，我们记录了所有MTC、SMTC和HMTC的年龄标准化发病率，分别为每年每10万人0.19、0.13和0.06。所有MTC、SMTC和HMTC发病率的年均变化百分比分别为1.0（=0.542）、2.8（=0.125）和-3.1（=0.324）。2015年1月1日的相应时点患病率分别为每10万人3.8、2.5和1.3。1998年至2015年期间，所有MTC、SMTC和HMTC患病率的年均变化百分比分别为2.8（<0.001）、3.8（<0.001）和1.5（=0.010）。我们发现所有MTC、SMTC和HMTC的发病率没有显著变化，可能是由于我们的样本量较小。然而，由于所有MTC发病率呈上升趋势，而SMTC（上升）和HMTC（下降）发病率呈相反趋势，其他人所观察到的所有MTC发病率的增加似乎可能是由SMTC组而非HMTC组驱动的。
