Di Daniele Nicola, Tesauro Manfredi, Mascali Alberto, Rovella Valentina, Scuteri Angelo
Hypertension Unit, Department of Internal Medicine, Policinico Tor Vergata, Università di Roma Tor Vergata, Rome, Italy.
Pulse (Basel). 2018 Mar;5(1-4):99-105. doi: 10.1159/000479701. Epub 2017 Sep 7.
Heart rate variability (HRV), pulse pressure amplification, and obesity represent risk factors for cardiovascular events. The aims of the present study are (1) to explore the impact of HRV on pulse pressure amplification and (2) to investigate whether the association between HRV and pulse pressure amplification differs in obese and lean subjects.
A total of 342 patients (age 61 ± 11 years) were enrolled. HRV was analyzed concerning both the frequency and time domain as well as concerning the HRV triangular index. Pulse pressure amplification was estimated as the ratio between brachial and carotid pulse pressure, the latter measured with SphygmoCor.
Time domain HRV indices were directly correlated with pulse pressure amplification (the lower the HRV indices, the lower the pulse pressure amplification). This association was stronger in obese than in lean subjects after controlling for age and sex.
Larger controlled studies are needed to provide a more detailed insight into the relation between HRV and pulse pressure amplification and to determine which pathways are differentially activated in lean and obese subjects.
心率变异性（HRV）、脉压放大和肥胖是心血管事件的危险因素。本研究的目的是：（1）探讨HRV对脉压放大的影响；（2）研究HRV与脉压放大之间的关联在肥胖和瘦体重受试者中是否存在差异。
共纳入342例患者（年龄61±11岁）。对HRV进行了频域、时域分析以及HRV三角指数分析。脉压放大以肱动脉与颈动脉脉压之比来估计，后者通过SphygmoCor测量。
时域HRV指标与脉压放大直接相关（HRV指标越低，脉压放大越低）。在控制年龄和性别后，这种关联在肥胖受试者中比在瘦体重受试者中更强。
需要开展更大规模的对照研究，以更详细地了解HRV与脉压放大之间的关系，并确定在瘦体重和肥胖受试者中哪些途径被不同程度地激活。
