Arbesú Miguel, Iruela Guillermo, Fuentes Héctor, Teixeira João M C, Pons Miquel
BioNMR Laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Barcelona, Spain.
Front Mol Biosci. 2018 Apr 30;5:39. doi: 10.3389/fmolb.2018.00039. eCollection 2018.
Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes. Focussing on the Src family of kinases, we argue that the intrinsically disordered domains that are unique for each of the family members and display a clear fingerprint of long range interactions in Src, might have critical roles as functional sensor or effectors and mediate allosteric communication via fuzzy interactions.
结构紊乱是许多蛋白质和蛋白质复合物发挥功能的重要因素。模糊复合物描述了许多紊乱作为蛋白质相互作用关键要素得以维持的情况。在这篇微型综述中，我们讨论分子内模糊相互作用在信号复合物中的作用方式。以Src激酶家族为重点，我们认为该家族每个成员所特有的内在无序结构域，在Src中显示出明显的长程相互作用特征，可能作为功能性传感器或效应器发挥关键作用，并通过模糊相互作用介导变构通讯。
