犬尿喹啉酸可阻断相关脑代谢产物喹啉酸在大鼠中诱导的神经毒性和癫痫发作。

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid.

作者信息

Foster A C, Vezzani A, French E D, Schwarcz R

出版信息

Neurosci Lett. 1984 Aug 10;48(3):273-8. doi: 10.1016/0304-3940(84)90050-8.

Abstract

Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.

摘要

犬尿喹啉酸（KYNA）作为与代谢相关的脑成分喹啉酸（QUIN）神经毒性和致癫痫作用的拮抗剂进行了测试。在大鼠纹状体中，KYNA优先阻断QUIN的神经毒性作用，而非其他兴奋性毒素的作用。在海马体中，KYNA拮抗局部应用QUIN所引起的神经退行性变和癫痫发作。KYNA的这些特性增加了其与脑中QUIN之间存在功能联系的可能性，这可能与理解人类神经退行性疾病有关。