Shemer A, Whitaker-Azmitia P M, Azmitia E C
Department of Biology, New York University, NY 10003.
Pharmacol Biochem Behav. 1988 Aug;30(4):847-51. doi: 10.1016/0091-3057(88)90109-8.
Parachlorophenylalanine (pCPA) or 5-methoxytryptamine (5MT) was administered to pregnant Sprague Dawley rats from day 8 (D8) of gestation till D17 and from D12 until birth respectively. Birth weights of both drug groups of neonates were approximately 20% less than the saline-injected controls. 5MT neonates showed a significant reduction of high affinity 3H-5HT uptake in the brainstem at all three time points: D1, D15, D30, and a slight reduction in the forebrain reaching significance only on D30. The pCPA animals showed a significant reduction in the brainstem and forebrain on D1 and D30, but only a small nonsignificant reduction in both areas on D15. Behaviors measured on day 15 revealed that in general activity, spontaneous alternation, and passive avoidance both drug groups of neonates showed deficits: less activity, less alternation, and less avoidance.
对妊娠第8天（D8）至第17天以及从第12天至出生的怀孕斯普拉格-道利大鼠分别给予对氯苯丙氨酸（pCPA）或5-甲氧基色胺（5MT）。两个药物组新生儿的出生体重均比注射生理盐水的对照组低约20%。5MT组新生儿在三个时间点（D1、D15、D30）脑干中高亲和力3H-5HT摄取均显著降低，前脑仅在D30有轻微降低且达到显著水平。pCPA组动物在D1和D30时脑干和前脑摄取显著降低，但在D15时两个区域仅有轻微的非显著降低。在第15天测量的行为显示，在总体活动、自发交替和被动回避方面，两个药物组的新生儿均表现出缺陷：活动减少、交替减少和回避减少。
