Nechaev D D, Bochko I I, Martynov I V, Kuz'mina L F
Ter Arkh. 1988;60(8):59-63.
The authors compared the action of small doses of aspirin (100-200 mg/day) and ticlopidine (500 mg/day) in multimodality therapy of acute myocardial infarction. Rapid normalization of aggregation time and disaggregation percentage, a sharp decrease in spontaneous aggregation before adding ADP were noted on the first 5 days of ticlopidine therapy. Platelet aggregation indices returned to normal 3-4 days earlier in the use of ticlopidine versus aspirin. However ticlopidine administration over 7 days was characterized by more frequent episodes of G. I. tract hemorrhages of short duration. There were also some data on the toxic effect of the drug on hepatocytes. More allergic reactions were observed in comparison with the group of patients on aspirin therapy. In order to achieve an optimal antiaggregation effect and to reduce the number of ticlopidine-related side effects short-term courses of ticlopidine with subsequent administration of aspirin at small doses were recommended.
作者比较了小剂量阿司匹林（100 - 200毫克/天）和噻氯匹定（500毫克/天）在急性心肌梗死多模式治疗中的作用。在噻氯匹定治疗的前5天，观察到聚集时间和解聚百分比迅速恢复正常，添加ADP前自发聚集急剧下降。与阿司匹林相比，使用噻氯匹定时血小板聚集指数提前3 - 4天恢复正常。然而，连续7天以上服用噻氯匹定的特点是胃肠道短时间出血发作更频繁。也有一些关于该药物对肝细胞毒性作用的数据。与接受阿司匹林治疗的患者组相比，观察到更多过敏反应。为了达到最佳抗聚集效果并减少与噻氯匹定相关的副作用数量，建议采用噻氯匹定短期疗程，随后小剂量服用阿司匹林。
