Hökfelt T, Foster G, Schultzberg M, Meister B, Schalling M, Goldstein M, Hemmings H C, Ouimet C, Greengard P
Department of Histology, Karolinska Institutet, Stockholm, Sweden.
Adv Exp Med Biol. 1988;235:65-82. doi: 10.1007/978-1-4899-2723-1_6.
The present article reviews some aspects of the localization of a dopamine- and cyclic AMP-regulated phosphoprotein, DARPP-32, which is assumed to be present in D-1 dopaminoceptive neurons. Its prenatal development starts at day 14 of gestation, is to a large extent complete at birth and seems to be independent of ingrowing dopamine-containing afferents. Rearrangements occur in certain areas, and in some systems DARPP-32 appears to be only transiently expressed. The presence of DARPP-32 in glial structures, the tanycytes, in the arcuate nucleus-median eminence complex in the mediobasal hypothalamus, has given further support to the hypothesis that dopamine, by controlling the shape of the tanycytes and the extension of their processes, can regulate LHRH release by a 'mechanical mechanism'. This hypothesis is now being examined in some experimental paradigms.
本文综述了多巴胺和环磷酸腺苷调节磷蛋白（DARPP - 32）的定位的某些方面，该蛋白被认为存在于D1多巴胺感受神经元中。其产前发育始于妊娠第14天，在出生时在很大程度上已完成，并且似乎独立于含多巴胺的传入神经的长入。在某些区域会发生重排，并且在一些系统中DARPP - 32似乎只是短暂表达。DARPP - 32在下丘脑基底内侧弓状核 - 正中隆起复合体的神经胶质结构即伸长细胞中的存在，进一步支持了这样的假说，即多巴胺通过控制伸长细胞的形状及其突起的延伸，可以通过“机械机制”调节促黄体生成素释放激素（LHRH）的释放。目前正在一些实验范式中检验这一假说。
