Department of Chemistry & Biochemistry , Miami University , Oxford , Ohio 45056 , United States.
Org Lett. 2018 Jun 1;20(11):3327-3331. doi: 10.1021/acs.orglett.8b01237. Epub 2018 May 15.
o-Phenylene tetramers have been coassembled with linkers into macrocycles through imine condensation. Variation of linker connectivity and length allows both [1 + 1] and [2 + 2] macrocycles to be obtained, complementing (previously reported) [3 + 3] macrocycles. For the [1 + 1] macrocycles, linker length has a clear effect on o-phenylene geometry and macrocycle stability. For the [2 + 2] macrocycles, both homo- and heterochiral configurations are observed, suggesting limited communication of helix handedness in these systems.
对苯四聚体通过亚胺缩合与连接子共组装成大环。改变连接子的连接性和长度，可以得到[1+1]和[2+2]大环，补充了（之前报道的）[3+3]大环。对于[1+1]大环，连接子的长度对苯环的几何形状和大环的稳定性有明显的影响。对于[2+2]大环，观察到同手性和异手性两种构象，表明在这些体系中螺旋手性的传递受到限制。
