Oak Ridge Institute for Science and Education, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sci Total Environ. 2018 Oct 1;637-638:881-891. doi: 10.1016/j.scitotenv.2018.05.074. Epub 2018 May 12.
The 2014 follow-up of the Anniston Community Health Survey (ACHS II) consisted of 338 surviving participants from the 2005-2007 baseline study (ACHS) who had previous polychlorinated biphenyl (PCB) measurements, were not pregnant, and were not institutionalized. Questionnaires and blood samples provided the demographic, personal history, and chemical concentration data of the Anniston residents. Approximately 51% of participants were African American, 72% were female, and the mean age was 63 years old. The objectives of this study were to provide an exposure assessment of dioxin-like chemicals in the ACHS II participants and compare the measurements with the general United States (U.S.) population via the National Health and Nutrition Examination Survey (NHANES). Stratified analyses revealed significantly higher average total dioxin toxic equivalencies (TEQs) among African Americans compared to Whites (33.1 vs. 19.2 pg/g lipid), and in females compared to males (29.8 vs. 17.0 pg/g lipid). When adjusting for age, sex, and race in linear regression, we found ACHS II participants to have significantly higher total dioxin TEQ than the general 2014 U.S. population that we estimated for using half-life and NHANES 2003/04 data (most recent NHANES individual samples data), by 16.7 pg/g lipid. Principal component analyses showed that non-ortho and mono-ortho PCBs were separated from the other dioxin-like chemicals among the Anniston residents, whereas the chemicals were all clustered together for estimated NHANES 2014. The concentrations of dioxin-like chemicals, especially non-ortho and mono-ortho PCBs, in Anniston residents who resided near the former PCB production plant were higher than those in the general U.S.
Although data strongly supported this difference, these inferences are limited because NHANES 2013/14 data were unavailable and we used estimated NHANES 2014 levels that we imputed from NHANES 2003/04 data in conjunction with half-life values estimated from Milbrath et al., 2009.
2014 年安尼斯顿社区健康调查（ACHS II）的随访包括 2005-2007 年基线研究（ACHS）中幸存的 338 名参与者，他们之前进行过多氯联苯（PCB）测量，未怀孕且未住院。问卷调查和血样提供了安尼斯顿居民的人口统计学、个人历史和化学浓度数据。大约 51%的参与者为非裔美国人，72%为女性，平均年龄为 63 岁。本研究的目的是评估 ACHS II 参与者体内二恶英类化学物质的暴露情况，并通过国家健康和营养检查调查（NHANES）将测量结果与美国普通人群进行比较。分层分析显示，非裔美国人的平均总二恶英毒性当量（TEQs）明显高于白人（33.1 比 19.2 pg/g 脂质），女性高于男性（29.8 比 17.0 pg/g 脂质）。在线性回归中，我们发现当调整年龄、性别和种族时，ACHS II 参与者的总二恶英 TEQ 明显高于我们根据半衰期和 NHANES 2003/04 数据（最近的 NHANES 个人样本数据）估计的 2014 年美国普通人群，差值为 16.7 pg/g 脂质。主成分分析显示，安尼斯顿居民体内的非邻位和单邻位多氯联苯与其他二恶英类化学物质分离，而这些化学物质在估计的 2014 年 NHANES 中则聚集在一起。安尼斯顿居民体内的二恶英类化学物质，尤其是非邻位和单邻位多氯联苯，在靠近前 PCB 生产厂的居民体内的浓度高于美国普通人群。
尽管数据强烈支持这种差异，但这些推论是有限的，因为 NHANES 2013/14 年的数据不可用，我们使用从 NHANES 2003/04 年数据推断并结合 Milbrath 等人 2009 年估计的半衰期值得到的估计的 2014 年 NHANES 水平。
