Lashkari Mahin, Noori Akram, Oveisi Sonia, Kheirkhah Mohammadreza
M.D., Rheumatologist, Assistant Professor, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
M.D., MPH, Ph.D. of Maternal and Child Health, Associate Professor, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Electron Physician. 2018 Mar 25;10(3):6500-6505. doi: 10.19082/6500. eCollection 2018 Mar.
It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.
The aim of this study was to determine the association of serum testosterone and DHEAs with RA.
This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 μg/dl in females and 88.9 μg/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19.
The mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953-0.979; p<0.001).
With regard to the results, abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA.
据推测，雄激素缺乏可能参与类风湿关节炎（RA）的发病机制。RA患者体液中的睾酮和硫酸脱氢表雄酮（DHEAs）水平会降低。
本研究旨在确定血清睾酮和DHEAs与RA之间的关联。
2014年，在伊朗加兹温医科大学对59例RA患者和61例年龄及性别匹配的健康对照者进行了这项病例对照研究。测量并比较两组的血清游离睾酮和DHEAs水平。女性血清睾酮水平低于0.029 ng/ml、男性低于2.49 ng/ml被视为异常。女性DHEAs水平低于18.9 μg/dl、男性低于88.9 μg/dl被视为异常。使用SPSS 19版软件通过独立样本T检验、卡方检验和逻辑回归分析对数据进行分析。
对照组女性的平均睾酮水平显著高于病例组女性。对照组的平均DHEAs水平显著高于病例组。病例组中睾酮和DHEAs水平异常者显著多于对照组。在调整年龄和性别后，逻辑回归分析显示仅DHEAs水平与RA存在独立关联（OR：0.966，95%CI：0.953 - 0.979；p<0.001）。
根据研究结果，RA患者的睾酮和DHEAs水平异常显著高于对照组。这表明性腺和肾上腺雄激素在RA中具有抗炎作用。
