Lin Qian, Zhao Jianfei, Xie Kun, Wang Yushi, Hu Guili, Jiang Guitao, Dai Qiuzhong, Fan Zhiyong, He Jianhua, He Xi, Hou De-Xing
College of Animal Science and Technology, Core Research Program 1515, Hunan Agricultural University, Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
The United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Anim Nutr. 2017 Jun;3(2):132-138. doi: 10.1016/j.aninu.2017.03.004. Epub 2017 Apr 4.
Magnolol rich in is a bioactive polyphenolic compound. The aim of this study was to examine the effects of magnolol additive (MA) on growth performance, expression levels of antioxidant-related genes, and intestinal mucosal morphology of ducks aged from 49 to 70 days, comparing with that of an antibiotic additive (colistin sulfate [CS]). A total of 275, 49-day-old ducks were assigned to 5 groups with 5 cages of 11 ducks each and fed diets supplemented with 0, 100, 200 and 300 mg of MA/kg and 300 mg of CS/kg for 3 weeks, respectively. The results showed that the average daily body weight gain (ADG) was increased significantly in MA-fed groups (200 and 300 mg/kg), compared with the basal diet (BD) group ( < 0.05). The mRNA levels of superoxide dismutase-1 (), manganese superoxide dismutase-2 () and catalase () were also increased significantly in MA groups ( < 0.05). In addition, hematoxylin and eosin staining revealed that ducks fed the diets with MA had more intact intestinal mucosa than those fed the BD and CS diets. In addition, ileal villus height, ileal villus height/crypt depth ratio (V/C) and duodenal V/C were also improved significantly ( < 0.05). Taken together, these data demonstrated that MA is an effective feed additive to enhance the growth performance of the ducks by improving the antioxidant and intestinal mucosal status, suggesting that MA will be a potential additive to replace antibiotic (CS).
厚朴酚是一种富含生物活性的多酚类化合物。本研究旨在探讨厚朴酚添加剂（MA）对49至70日龄鸭生长性能、抗氧化相关基因表达水平及肠道黏膜形态的影响，并与抗生素添加剂（硫酸黏菌素[CS]）进行比较。将275只49日龄的鸭分为5组，每组5个笼子，每个笼子11只鸭，分别饲喂添加0、100、200和300 mg/kg MA以及300 mg/kg CS的日粮，为期3周。结果表明，与基础日粮（BD）组相比，MA饲喂组（200和300 mg/kg）的平均日增重（ADG）显著增加（P<0.05）。MA组中超氧化物歧化酶-1（SOD-1）、锰超氧化物歧化酶-2（MnSOD）和过氧化氢酶（CAT）的mRNA水平也显著增加（P<0.05）。此外，苏木精-伊红染色显示，饲喂含MA日粮的鸭肠道黏膜比饲喂BD和CS日粮的鸭更完整。此外，回肠绒毛高度、回肠绒毛高度/隐窝深度比值（V/C）和十二指肠V/C也显著提高（P<0.05）。综上所述，这些数据表明，MA是一种有效的饲料添加剂，可通过改善抗氧化和肠道黏膜状态来提高鸭的生长性能，表明MA将是替代抗生素（CS）的潜在添加剂。
