The production of tumor necrosis factor-alpha by rat basophilic leukemia cells with triggering IgE receptor.
作者信息
Ohno I, Tanno Y, Yamauchi K, Ida S, Takishima T
机构信息
The First Department of Internal Meicine, Tohoku University School of Medicine, Sendai.
出版信息
Tohoku J Exp Med. 1988 Oct;156(2):209-10. doi: 10.1620/tjem.156.209.
PMID:2976997
Abstract
We evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-alpha (mTNF-alpha) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-alpha.
摘要
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