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2
Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.针对细菌细胞壁生物合成抑制剂的拮抗筛选发现了一种十一异戊烯基二磷酸合酶抑制剂。
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11048-53. doi: 10.1073/pnas.1511751112. Epub 2015 Aug 17.
3
Arginine-containing peptides as potent inhibitors of VIM-2 metallo-β-lactamase.含精氨酸肽作为VIM-2金属β-内酰胺酶的强效抑制剂。
Biochim Biophys Acta. 2015 Nov;1850(11):2228-38. doi: 10.1016/j.bbagen.2015.07.012. Epub 2015 Aug 1.
4
Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.药物发现检测:用作β-内酰胺酶底物的头孢硝噻吩类似物的合成与测试。
Anal Biochem. 2015 Oct 1;486:75-7. doi: 10.1016/j.ab.2015.06.032. Epub 2015 Jul 2.
5
The biology of Mur ligases as an antibacterial target.Mur连接酶作为抗菌靶点的生物学特性。
Mol Microbiol. 2014 Oct;94(2):242-53. doi: 10.1111/mmi.12758. Epub 2014 Sep 5.
6
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Antimicrob Agents Chemother. 2014 Jul;58(7):4005-13. doi: 10.1128/AAC.02388-13. Epub 2014 May 5.
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Discovery of novel cell wall-active compounds using P ywaC, a sensitive reporter of cell wall stress, in the model gram-positive bacterium Bacillus subtilis.在模式革兰氏阳性菌枯草芽孢杆菌中,利用细胞壁应激敏感报告基因P ywaC发现新型细胞壁活性化合物。
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8
Characterization of cefoxitin-resistant Escherichia coli isolates from recreational beaches and private drinking water in Canada between 2004 and 2006.2004年至2006年期间从加拿大休闲海滩和私人饮用水中分离出的耐头孢西丁大肠杆菌菌株的特性分析
Antimicrob Agents Chemother. 2009 Jul;53(7):3126-30. doi: 10.1128/AAC.01353-08. Epub 2009 Apr 27.
9
Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study.加拿大急症护理医院收治的成年患者中与医疗保健相关的艰难梭菌感染:一项加拿大医院感染监测项目研究
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Antimicrobial susceptibilities of Campylobacter jejuni isolates from poultry from Alberta, Canada.来自加拿大艾伯塔省家禽的空肠弯曲菌分离株的抗菌药敏性。
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加拿大卫生研究院对抗菌素耐药性的应对措施。

The Canadian Institutes of Health Research response to antimicrobial resistance.

作者信息

Pagé E L, Desnoyers S, Létourneau I J, Keown K, Jackson A, Ouellette M

机构信息

Canadian Institutes of Health Research, Institute of Infection and Immunity, Québec, QC.

Canadian Institutes of Health Research, Ottawa, ON.

出版信息

Can Commun Dis Rep. 2015 Nov 19;41(Suppl 5):11-15. doi: 10.14745/ccdr.v41is5a03.

DOI:10.14745/ccdr.v41is5a03
PMID:29769970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5868538/
Abstract

Antimicrobial resistance (AMR) has been a research priority for the Canadian Institutes of Health Research (CIHR), Institute of Infection and Immunity (III) since its inception, and a number of strategic research initiatives have been launched to address this global health problem by promoting and supporting research related to mechanisms and processes that impact the emergence and spread of resistance among individuals and within the environment. Here we will present research initiatives on AMR led by CIHR-III, which include national programs as well as international partnerships with the United Kingdom and the European Union, in addition to interesting outcomes of these initiatives.

摘要

自成立以来,抗菌药物耐药性(AMR)一直是加拿大卫生研究院(CIHR)感染与免疫研究所(III)的研究重点。通过促进和支持与影响个体及环境中耐药性产生和传播的机制及过程相关的研究,已经启动了多项战略研究计划来解决这一全球健康问题。在此,我们将介绍由CIHR-III牵头的关于抗菌药物耐药性的研究计划,其中包括国家项目以及与英国和欧盟的国际合作关系,此外还将介绍这些计划取得的有趣成果。