UCL Cancer Institute, University College London, London, United Kingdom.
UCL Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Front Immunol. 2018 May 2;9:963. doi: 10.3389/fimmu.2018.00963. eCollection 2018.
The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies.
皮肤是移植物抗宿主病（GVHD）最常见的靶器官，其严重程度和对治疗的反应是患者生存的重要预测指标。尽管GVHD 发病机制中的许多起始事件已经得到定义，但对于治疗抵抗的发生原因以及为何经常无法永久恢复组织内稳态的原因知之甚少。新出现的数据表明，皮肤中独特的免疫微环境负责定义损伤的位置和特定机制，这些机制与其他靶器官中的损伤机制不同。在这篇综述中，我们讨论了对皮肤中 GVHD 生物学的理解的最新进展，并概述了最终将能够设计精准治疗的新研究主题。
