Shah Nehal R, Leone Alexa, Rothbaum Robert, Delost Gregory Rr, Cooper Kevin
Medicine, Touro College of Osteopathic Medicine, New York, USA.
Dermatology, University Hospitals Cleveland Medical Center, Cleveland, USA.
Cureus. 2019 May 7;11(5):e4614. doi: 10.7759/cureus.4614.
Graft-versus-host disease (GVHD) is a common complication following patients who have undergone allogenic hematopoietic stem cell transplantation (allo-HSCT). While GVHD has been previously sub-categorized through a temporal relationship upon transplantation, revisions from the National Institutes of Health have modified the diagnosis criteria to be more involved with specific signs and symptoms. Chronic classifications of GVHD include non-sclerotic and sclerotic forms, and the sclerotic form can be further classified based on morphologies such as lichen-sclerosis-like, sclerodermoid or morphea-like plaques. Generalized morphea can have similar histopathological findings but in order to be diagnosed, certain diagnostic criteria must be met. Herein, we report a patient with linear and inflammatory morphea morphology of chronic GVHD, which presents symmetrically on both lower extremities.
移植物抗宿主病（GVHD）是同种异体造血干细胞移植（allo-HSCT）患者常见的并发症。虽然此前GVHD是根据移植后的时间关系进行亚分类的，但美国国立卫生研究院的修订版已将诊断标准修改为更多地涉及特定的体征和症状。慢性GVHD的分类包括非硬化型和硬化型，硬化型可根据苔藓样硬化、硬皮病样或硬斑病样斑块等形态进一步分类。泛发性硬斑病可能有类似的组织病理学表现，但要确诊必须满足某些诊断标准。在此，我们报告一名患有慢性GVHD线性炎症性硬斑病形态的患者，其双下肢呈对称性表现。
