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布地奈德盐水鼻腔冲洗治疗儿童鼻-鼻窦炎

[Budesonide saline nasal irrigation in treatment of children rhino-sinusitis].

作者信息

Tang L X, Gao J, Zhang Y M

机构信息

Department of Otorhinolaryngology,Beijing Children's Hospital,Capital Medical University,Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery,Beijing,100045,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jun 20;30(12):952-954. doi: 10.13201/j.issn.1001-1781.2016.12.008.

Abstract

To study the effect of nasal irrigation in treatment of children rhinosinusitis.To compare the effect with different nasal irrigation methods and nasal spray with budesonide.Seventy-five patients with rhinosinusitis were divided randomly into four groups.Nasal irrigation with saline(20 cases),treated with budesonide nasal spray(20 cases),nasal irrigation with saline and budesonide(20 cases),nasal spray with 2.3% hypertonic saline (15 cases).Saccharin clearance time,physical examination of the nose and the quality of life were used to evaluate the efficiency at the beginning of the treatment,one and two weeks after the treatment,respectively.After the therapy,the index of saccharin clearance time,physical examination of the nose and the quality of life were improved in each group.The budesonide and normal saline group is the greatest one.And then,the efficiency of treatment is budesonide nasal spray group >the 2.3% hypertonic saline group>the normal saline group.The differences between each group were significant.Nasal irrigation is a useful treatment in children rhinosinusitis.The efficiency of saline irrigation is less than budesonide aerosol spray.Add budesonide to the irrigation fluid combines the effect of the budesonide with irrigation and get more efficiency of treatment.

摘要

研究鼻腔冲洗治疗儿童鼻窦炎的效果。比较不同鼻腔冲洗方法及布地奈德鼻喷雾剂的效果。75例鼻窦炎患儿随机分为四组:生理盐水鼻腔冲洗组(20例)、布地奈德鼻喷雾剂治疗组(20例)、生理盐水联合布地奈德鼻腔冲洗组(20例)、2.3%高渗盐水鼻喷雾剂组(15例)。分别于治疗开始时、治疗1周及2周后,采用糖精清除时间、鼻部体格检查及生活质量评估疗效。治疗后,各组糖精清除时间、鼻部体格检查及生活质量指标均有改善。布地奈德与生理盐水组改善最明显。然后,治疗有效率为布地奈德鼻喷雾剂组>2.3%高渗盐水组>生理盐水组。各组间差异有统计学意义。鼻腔冲洗是治疗儿童鼻窦炎的有效方法。生理盐水冲洗的疗效低于布地奈德气雾剂。在冲洗液中加入布地奈德可将布地奈德与冲洗的作用结合起来,获得更高的治疗效果。

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