Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Neuron. 2018 May 16;98(4):673-675. doi: 10.1016/j.neuron.2018.05.002.
Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.
Ataxin-2 是一种 RNA 结合蛋白，参与翻译调控，在包括 ALS 在内的神经退行性疾病中发生突变。在本期《神经元》杂志中，Bakthavachalu 等人（2018）证明，高阶 Ataxin-2 RNA/蛋白复合物对于果蝇的翻译依赖性学习和与 ALS 相关的神经退行性变都是必需的。
