School of Chinese Medicine, Heilongjiang University of Chinese Medicine, Heilongjiang, China.
Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, 518057, China.
Food Chem Toxicol. 2018 Sep;119:50-60. doi: 10.1016/j.fct.2018.05.037. Epub 2018 May 14.
Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans. To date, over 10,000 PAs poisoning cases have been reported worldwide. In recent years, many articles have reported the detection of PAs in various foods, including honey, milk, meat, eggs, tea and salad. This review summarized the contamination of PAs in foods, state of the art detection methods and regulations by different countries and authorities, hoping to propose effective solutions to minimize the consumption of PAs in food.
吡咯里西啶生物碱（PAs）是植物的次生代谢物。已有报道称 PAs 具有肝毒性、致突变性和致癌性；它们是一组重要的天然毒素，影响着家畜、野生动物和人类。迄今为止，全世界已报告了超过 10000 例 PAs 中毒病例。近年来，许多文章报道了 PAs 在各种食品中的存在，包括蜂蜜、牛奶、肉类、蛋类、茶和沙拉。本综述总结了 PAs 在食品中的污染情况、不同国家和机构采用的最新检测方法以及相关法规，希望提出有效解决方案，尽量减少食品中 PAs 的摄入。
