State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Fitoterapia. 2018 Jul;128:162-168. doi: 10.1016/j.fitote.2018.05.015. Epub 2018 May 24.
Four new indole alkaloids, melodinusines A-D (1, 2, 6, and 7), along with 26 known indole alkaloids, were isolated from Melodinus tenuicaudatus and Melodinus khasianus (Melodinus genus). Among them, 1 and 2 are aspidospermine-aspidospermine-type bisindole alkaloids while 7 is a novel melodinus-type alkaloid. Their structures were established on the basis of comprehensive spectroscopic data analysis and the structure of 7 was further confirmed by single-crystal X-ray diffraction analysis. Their cytotoxic activities against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480 were also evaluated.
从密花轮环藤（Melodinus tenuicaudatus）和尼泊尔轮环藤（Melodinus khasianus）（密花轮环藤属）中分离得到了 4 个新的吲哚生物碱，即 melodinusines A-D（1、2、6 和 7），以及 26 个已知的吲哚生物碱。其中，1 和 2 为表阿朴-表阿朴长春胺型双吲哚生物碱，而 7 是一种新的密花轮环藤型生物碱。基于综合光谱数据分析确定了它们的结构，通过单晶 X 射线衍射分析进一步确定了 7 的结构。还评估了它们对五种人癌细胞系 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 的细胞毒性活性。
